Adjuvant chemotherapy may improve disease-free survival in patients with rectal cancer positive for MRI-detected extramural venous invasion following chemoradiation.

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Abstract

MRI-detected extramural venous invasion (mrEMVI) is a poor prognostic factor in rectal cancer. Preoperative chemoradiotherapy (CRT) can cause regression in the severity of EMVI and subsequently improve survival whereas mrEMVI persisting after CRT confers an increased risk of recurrence. The effect of adjuvant chemotherapy (AC) following CRT on survival in rectal cancer remains unclear. The aim of this study was to determine whether there is a survival advantage for AC given to patients with mrEMVI persisting after CRT.

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Journal

Journal ID (iso-abbrev): Colorectal Dis

Title: Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland

Publisher: Wiley

ISSN (Electronic): 1463-1318

ISSN (Print): 1462-8910

Publication date (Electronic): Jun 2017

Volume: 19

Issue: 6

Affiliations

[1 ] Department of Surgery, University College London Hospital, London, UK.

[2 ] Department of Radiology, Royal Marsden Hospital, Sutton, UK.

[3 ] Department of Surgery and Cancer, Imperial College London, London, UK.

[4 ] Department of Surgery and Cancer, Royal Marsden Hospital, London, UK.

[5 ] Pelican Cancer Foundation, Basingstoke, UK.

[6 ] Croydon University Hospital, London, UK.

[7 ] Department of Pathology and Molecular Biology, Leeds University Hospital, Leeds, UK.

Article

DOI: 10.1111/codi.13535

PubMed ID: 27673438

SO-VID: 20c571b0-0e66-4368-925a-d362955b75ae

History

Keywords: rectal cancer,venous invasion,MRI,chemotherapy

Data availability:

Keywords: rectal cancer, venous invasion, MRI, chemotherapy

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