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Monitoring pharmacokinetics of anticancer drugs: non-invasive investigation using magnetic resonance spectroscopy
March 2000
March 2000
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Abstract
Magnetic resonance spectroscopy (MRS) offers the unique advantage of detecting, identifying
and quantifying chemicals deep within the living body in a totally non-invasive manner.
In studies on pharmacology and toxicology of anticancer drugs, MRS and the closely
related technique magnetic resonance imaging (MRI) have many uses. MRS in particular,
despite its low sensitivity, offers unique insights into pharmacokinetics (the changing
concentration of the drug at its site of action) which can be monitored, and metabolism
(both activation and detoxification) can be detected in real time. This review considers
some recent work on (19)F, (31)P, (1)H and (13)C MRS of anticancer drugs. Future possibilities
for (13)C MRS and (1)H MRS studies of drugs and their metabolites are considered in
detail.