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      Neurohypophysial Hormones in the Adrenal Medulla*

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      The Journal of Clinical Endocrinology & Metabolism

      The Endocrine Society

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          Abstract

          Immunoreactive oxytocin and arginine vasopressin (AVP) were measured in the adrenal medulla of both rat and man as well as in tissue from two pheochromocytomas using highly specific RIAs. In all instances, oxytocin predominated over AVP. The concentrations of oxytocin ranged from 19.9-162.7 pg/g tissue, whereas those for AVP were 9.8-102 pg/g. These values are far greater than those found in plasma. The oxytocin- and AVP-related neurophysins were also present in large quantities in human adrenal medulla and pheochromocytoma. Identity of the peptides was confirmed by demonstrating parallel immunoreactivity with standard compounds and by the high performance liquid chromatographic profiles. In experiments carried out in rats, the source of the adrenal medullary AVP and oxytocin did not appear to be the paraventricular nucleus. It is postulated that the neurohypophysial peptides may have a regulatory function in the secretion of catecholamines.

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          Author and article information

          Journal
          The Journal of Clinical Endocrinology & Metabolism
          The Journal of Clinical Endocrinology & Metabolism
          The Endocrine Society
          0021-972X
          1945-7197
          April 1984
          April 1984
          : 58
          : 4
          : 688-691
          Article
          10.1210/jcem-58-4-688
          6699132
          © 1984

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