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      Intrinsic Prostaglandin Release

      Journal of Vascular Research

      S. Karger AG

      Anoxia-induced relaxation, Coronary artery, Prostaglandin-mediated relaxation

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          Isolated coronary artery strips of the bovine heart in vitro relax in response to decreased bath oxygen tensions (from 515 mm Hg to 112, 53, and 38 mm Hg). In addition, the rate of intrinsic formation and release of prostaglandin is considerably increased under conditions of decreased PO<sub>2</sub>. The vascular relaxations under reduced PO<sub>2</sub> are attenuated and the elevations in prostaglandin output blocked by prostaglandin synthesis inhibitors. It appears that alterations in the output of a PGE with vasodilator activity, probably E<sub>1</sub>, is a significant factor regulating the compensatory changes in tone of the coronary arteries in response to anoxic conditions.

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          Author and article information

          J Vasc Res
          Journal of Vascular Research
          S. Karger AG
          18 September 2008
          : 13
          : 3
          : 155-166
          Department of Pharmacology, Faculty of Medicine, University of Ottawa, Ottawa
          158086 Blood Vessels 1976;13:155–166
          © 1976 S. Karger AG, Basel

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          Pages: 12
          Research Paper


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