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      Privileged scaffolds for library design and drug discovery.

      Current Opinion in Chemical Biology
      Elsevier BV

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          Abstract

          This review explores the concept of using privileged scaffolds to identify biologically active compounds through building chemical libraries. We hope to accomplish three main objectives: to provide one of the most comprehensive listings of privileged scaffolds; to reveal through four selected examples the present state of the art in privileged scaffold library synthesis (in hopes of inspiring new and even more creative approaches); and also to offer some thoughts on how new privileged scaffolds might be identified and exploited.

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          Journal
          20303320
          2908274
          10.1016/j.cbpa.2010.02.018

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