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      Apigenin attenuates diabetes-associated cognitive decline in rats via suppressing oxidative stress and nitric oxide synthase pathway.

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          Abstract

          Our present investigation aimed to determine the neuroprotection of apigenin (API) against diabetes-associated cognitive decline (DACD) a diabetic rat model and exploring its potential mechanism. Diabetic rat model was induced by intraperitoneal injection of streptozotocin. All experiment animals treated with vehicle or API by doses of 10, 20 and 40 mg/kg for seven weeks. Firstly, the body weight and blood glucose levels were detected. We used Morris water maze test to evaluate learning and memory function. The oxidative indicators (malondialdehyde (MDA), superoxide dismutase (SOD) and glutathione (GSH)), cNOS, iNOS, caspase-3 and caspase-9 were measured in cerebral cortex and hippocampus using corresponding commercial kits. API can increase body weight, reduce the blood glucose levels, and improve the cognitive function in rats induced by diabetes. API decrease the MDA content, and increase SOD activity and GSH level of diabetic animals in the cerebral cortex and hippocampus of diabetic rats. Meanwhile, constitutive nitric oxide synthase (cNOS), inducible nitric oxide synthase (iNOS), caspase-3/9 were markedly exhibited in the cerebral cortex and hippocampus of diabetic rats. In summary, our current work discloses that API attenuates DACD in rats via suppressing oxidative stress, nitric oxide and apoptotic cascades synthase pathway.

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          Author and article information

          Journal
          Int J Clin Exp Med
          International journal of clinical and experimental medicine
          1940-5901
          2015
          : 8
          : 9
          Affiliations
          [1 ] Department of Clinical Pharmacology, Xiangya Hospital, Central South University Changsha 410008, P. R. China ; Institute of Clinical Pharmacology, Central South University; Hunan Key Laboratory of Pharmacogenetics Changsha 410078, P. R. China.
          Article
          4658930
          26629041
          2123cbba-d0fa-45b5-9cb4-e5e243fe46cd
          History

          Apigenin,diabetes,diabetes-associated cognitive decline,nitric oxide,oxidative stress

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