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      Emerging techniques in single-cell epigenomics and their applications to cancer research

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          Abstract

          Epigenomics encompasses studies of the chemical modifications of genomic DNA and associated histones, interactions between genomic DNA sequences and proteins, the dynamics of the chromosomal conformation, the functional relationships between these epigenetic events, and the regulatory impacts of these epigenetic events on gene expression in cells. In comparison to current techniques that are only capable of characterizing average epigenomic features across bulk cell ensembles, single-cell epigenomic methodologies are emerging as powerful new techniques to study cellular plasticity and heterogeneity, as seen in stem cells and cancer. Here we summarize available techniques for studies of single-cell epigenomics, review their current applications to cancer research, and discuss future possibilities. This review also highlights that the full potential of single-cell epigenetic studies will be comprehended through integrating the multi-omics information of genomics, epigenomics and transcriptomics.

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          Author and article information

          Journal
          101729941
          47742
          J Clin Genom
          Journal of clinical genomics
          9 July 2018
          05 March 2018
          2018
          01 August 2018
          : 1
          : 1
          : 10.4172/JCG.1000103
          Affiliations
          Department of Biochemistry and Molecular Biology, Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, MD 21201, USA
          Author notes
          [* ] Correspondence to: Qun Zhou, M.D., Ph.D., Associate Professor, Department of Biochemistry and Molecular Biology, Greenebaum Cancer Center, University of Maryland School of Medicine, 108 N. Greene Street, Baltimore, MD 21201, USA., qzhou@ 123456som.umaryland.edu , Telephone: +1-410-706-1615; Fax: +1-410-706-8297
          Article
          PMC6070152 PMC6070152 6070152 nihpa977557
          6070152
          30079405
          2128c03e-8e8f-4b0b-a2b3-c8e6e7fb0bc6
          History
          Categories
          Article

          intratumor heterogeneity,single-cell techniques,Chemotherapeutic treatments,Oncogenesis,Genomic DNA,Epigenomics

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