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      Heat shock protein expression and temperature distribution in prostate tumours treated with laser irradiation and nanoshells.

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          Abstract

          Sub-lethal temperature elevations in the tumour incurred during laser cancer therapy can induce heat shock protein (HSP) expression leading to enhanced tumour survival and recurrence. Nanoshells utilised in combination with laser therapy can potentially enable selective heat deposition, greater thermal injury, and diminished HSP expression in the tumour. The study objective was to measure the distribution of temperature and HSP expression in prostate tumours in response to laser therapy alone or with nanoshells to determine if these combinatorial therapies can minimise HSP expression.

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          Author and article information

          Journal
          Int J Hyperthermia
          International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group
          Informa UK Limited
          1464-5157
          0265-6736
          2011
          : 27
          : 8
          Affiliations
          [1 ] Virginia Tech-Wake Forest School of Biomedical Engineering and Sciences and Department of Mechanical Engineering, Blacksburg, VA 24060, USA. mnr@vt.edu
          Article
          10.3109/02656736.2011.607485
          22098363
          213a3a2a-87af-4e05-a17b-694572bce2ad
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