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      Association of classroom ventilation with reduced illness absence: a prospective study in California elementary schools

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          Abstract

          Limited evidence associates inadequate classroom ventilation rates ( VRs) with increased illness absence ( IA). We investigated relationships between VRs and IA in California elementary schools over two school years in 162 3rd–5th‐grade classrooms in 28 schools in three school districts: South Coast ( SC), Bay Area ( BA), and Central Valley ( CV). We estimated relationships between daily IA and VR (estimated from two year daily real‐time carbon dioxide in each classroom) in zero‐inflated negative binomial models. We also compared IA benefits and energy costs of increased VRs. All school districts had median VRs below the 7.1 l/s‐person California standard. For each additional 1 l/s‐person of VR, IA was reduced significantly (p<0.05) in models for combined districts (−1.6%) and for SC (−1.2%), and nonsignificantly for districts providing less data: BA (−1.5%) and CV (−1.0%). Assuming associations were causal and generalizable, increasing classroom VRs from the California average (4 l/s‐person) to the State standard would decrease IA by 3.4%, increase attendance‐linked funding to schools by $33 million annually, and increase costs by only $4 million. Further increasing VRs would provide additional benefits. These findings, while requiring confirmation, suggest that increasing classroom VRs above the State standard would substantially decrease illness absence and produce economic benefits.

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          Most cited references20

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          Risk of indoor airborne infection transmission estimated from carbon dioxide concentration.

          The Wells-Riley equation, which is used to model the risk of indoor airborne transmission of infectious diseases such as tuberculosis, is sometimes problematic because it assumes steady-state conditions and requires measurement of outdoor air supply rates, which are frequently difficult to measure and often vary with time. We derive an alternative equation that avoids these problems by determining the fraction of inhaled air that has been exhaled previously by someone in the building (rebreathed fraction) using CO2 concentration as a marker for exhaled-breath exposure. We also derive a non-steady-state version of the Wells-Riley equation which is especially useful in poorly ventilated environments when outdoor air supply rates can be assumed constant. Finally, we derive the relationship between the average number of secondary cases infected by each primary case in a building and exposure to exhaled breath and demonstrate that there is likely to be an achievable critical rebreathed fraction of indoor air below which airborne propagation of common respiratory infections and influenza will not occur.
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            Ventilation rates and health: multidisciplinary review of the scientific literature.

            The scientific literature through 2005 on the effects of ventilation rates on health in indoor environments has been reviewed by a multidisciplinary group. The group judged 27 papers published in peer-reviewed scientific journals as providing sufficient information on both ventilation rates and health effects to inform the relationship. Consistency was found across multiple investigations and different epidemiologic designs for different populations. Multiple health endpoints show similar relationships with ventilation rate. There is biological plausibility for an association of health outcomes with ventilation rates, although the literature does not provide clear evidence on particular agent(s) for the effects. Higher ventilation rates in offices, up to about 25 l/s per person, are associated with reduced prevalence of sick building syndrome (SBS) symptoms. The limited available data suggest that inflammation, respiratory infections, asthma symptoms and short-term sick leave increase with lower ventilation rates. Home ventilation rates above 0.5 air changes per hour (h(-1)) have been associated with a reduced risk of allergic manifestations among children in a Nordic climate. The need remains for more studies of the relationship between ventilation rates and health, especially in diverse climates, in locations with polluted outdoor air and in buildings other than offices. Ventilation with outdoor air plays an important role influencing human exposures to indoor pollutants. This review and assessment indicates that increasing ventilation rates above currently adopted standards and guidelines should result in reduced prevalence of negative health outcomes. Building operators and designers should avoid low ventilation rates unless alternative effective measures, such as source control or air cleaning, are employed to limit indoor pollutant levels. © 2011 John Wiley & Sons A/S.
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              Indoor air quality, ventilation and health symptoms in schools: an analysis of existing information.

              We reviewed the literature on Indoor Air Quality (IAQ), ventilation, and building-related health problems in schools and identified commonly reported building-related health symptoms involving schools until 1999. We collected existing data on ventilation rates, carbon dioxide (CO2) concentrations and symptom-relevant indoor air contaminants, and evaluated information on causal relationships between pollutant exposures and health symptoms. Reported ventilation and CO2 data strongly indicate that ventilation is inadequate in many classrooms, possibly leading to health symptoms. Adequate ventilation should be a major focus of design or remediation efforts. Total volatile organic compounds, formaldehyde (HCHO) and microbiological contaminants are reported. Low HCHO concentrations were unlikely to cause acute irritant symptoms (<0.05 ppm), but possibly increased risks for allergen sensitivities, chronic irritation, and cancer. Reported microbiological contaminants included allergens in deposited dust, fungi, and bacteria. Levels of specific allergens were sufficient to cause symptoms in allergic occupants. Measurements of airborne bacteria and airborne and surface fungal spores were reported in schoolrooms. Asthma and 'sick building syndrome' symptoms are commonly reported. The few studies investigating causal relationships between health symptoms and exposures to specific pollutants suggest that such symptoms in schools are related to exposures to volatile organic compounds (VOCs), molds and microbial VOCs, and allergens.
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                Author and article information

                Journal
                Indoor Air
                Indoor Air
                10.1111/(ISSN)1600-0668
                INA
                Indoor Air
                John Wiley and Sons Inc. (Hoboken )
                0905-6947
                1600-0668
                22 April 2013
                December 2013
                : 23
                : 6 ( doiID: 10.1111/ina.2013.23.issue-6 )
                : 515-528
                Affiliations
                [ 1 ] Indoor Environment Group Environmental Energy Technologies Division Lawrence Berkeley National Laboratory Berkeley CA USA
                Author notes
                [*] [* ] M. J. Mendell

                Lawrence Berkeley National Laboratory

                1 Cyclotron Road, MS 90‐3058

                Berkeley, CA 94720, USA

                Tel.: +510‐486‐5762

                Fax: +510‐486‐6658

                e‐mail: mjmendell@ 123456lbl.gov

                Article
                INA12042
                10.1111/ina.12042
                7165692
                23506393
                214499c6-5437-4ad9-9899-5d49413366fe
                Published 2013. This article is a US Government work and is in the public domain in the USA

                This article is being made freely available through PubMed Central as part of the COVID-19 public health emergency response. It can be used for unrestricted research re-use and analysis in any form or by any means with acknowledgement of the original source, for the duration of the public health emergency.

                History
                : 30 November 2012
                : 12 March 2013
                Page count
                Pages: 14
                Funding
                Funded by: California Energy Commission
                Funded by: Assistant Secretary for Energy Efficiency and Renewable Energy
                Funded by: US Department of Energy
                Award ID: DE‐AC02‐05CH11231
                Categories
                Original Article
                Original Articles
                Custom metadata
                2.0
                December 2013
                Converter:WILEY_ML3GV2_TO_JATSPMC version:5.8.0 mode:remove_FC converted:15.04.2020

                Health & Social care
                carbon dioxide,indoor environmental quality,schools,ventilation,illness absence

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