Large-scale gene-expression studies and the challenge of multiple sclerosis

Abstract

Recent transcription-profiling studies have found distinct gene-expression patterns in multiple sclerosis; such large-scale studies at different stages of the disease are contributing to understanding multiple sclerosis and developing effective therapy.

Abstract

In multiple sclerosis, a complex neurodegenerative disorder, a combination of genetic and environmental factors results in inflammation and myelin damage. Recent transcription-profiling studies have found distinct gene-expression patterns in diseased tissue; such large-scale studies at different stages of the disease are contributing to understanding multiple sclerosis and developing effective therapy.