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      Efficient Synthesis of C3-Alkylated and Alkenylated Indoles via Manganese-Catalyzed Dehydrogenation.

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          Abstract

          The catalytic dehydrogenation of alcohols is essential for the sustainable production of valuable products. This provides a new strategy for green organic synthesis in chemical industries. Herein, we describe a manganese-based catalytic system that enables the efficient synthesis of C3-alkylated indoles from benzyl alcohols and indoles via the borrowing hydrogen process. Furthermore, dehydrogenative coupling of 2-arylethanols and indoles yields C3-alkenylated indoles. Meanwhile, reacting 2-aminophenethanol instead of indoles can also obtain the corresponding indole products with high selectivity under the same conditions.

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          Author and article information

          Journal
          Chem Asian J
          Chemistry, an Asian journal
          Wiley
          1861-471X
          1861-471X
          Sep 01 2022
          : 17
          : 17
          Affiliations
          [1 ] Flavors and Fragrance Engineering & Technology Research Center of Henan Province, College of Tobacco Science, Henan Agricultural University, Zhengzhou, 450002, P. R. China.
          Article
          10.1002/asia.202200483
          35771722
          215e49ff-976d-40b0-9128-6ed223b97f07
          History

          alkenylation,alkylation,dehydrogenation,indoles,manganese catalysis

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