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      Intrarenal Prostaglandins: Effect of Sodium and Indomethacin on PGE 2 and PGF 2α in Rabbits

      , , ,

      Nephron

      S. Karger AG

      Intrarenal prostaglandin, Sodium loading, Indomethacin

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          Abstract

          The levels of prostaglandins (PG S) E<sub>2</sub> and F<sub>2</sub>α in different parts of the rabbit kidney were determined to observe the effect of sodium and indomethacin. After the pretreatment with injections of saline or with indomethacin, tissues from inner and outer medulla and cortex were separated, extracted, analyzed for PGE<sub>2</sub> and PGF<sub>2</sub>α by radioimmunoassay. In the normal rabbit kidney, the greatest amount of PG was found in the inner medulla. Saline injections appeared to increase PGE<sub>2</sub> (but not PGF<sub>2</sub>α), especially in the inner medulla. Repeated injections of saline, on the other hand, markedly reduced PGE<sub>2</sub> in the inner medulla but increased outer medullary PGE<sub>2</sub>. Indomethacin reduced the production of PG S in all kidney segments. These results suggest the bidirectional effect of sodium on PG concentration in the rabbit kidney. Acute administration of sodium may directly stimulate the synthesis of PGE<sub>2</sub> in the inner medulla but chronic stimulation with sodium may alter the pattern of PGE<sub>2</sub> synthesis.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1979
          1979
          02 December 2008
          : 24
          : 6
          : 283-286
          Affiliations
          Department of Urology, Kumamoto University Medical School, Kumamoto
          Article
          181737 Nephron 1979;24:283–286
          10.1159/000181737
          514428
          © 1979 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 4
          Categories
          Original Paper

          Cardiovascular Medicine, Nephrology

          Indomethacin, Sodium loading, Intrarenal prostaglandin

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