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      mTOR: from growth signal integration to cancer, diabetes and ageing

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          Abstract

          In all eukaryotes, the target of rapamycin (TOR) signalling pathway couples energy and nutrient abundance to the execution of cell growth and division, owing to the ability of TOR protein kinase to simultaneously sense energy, nutrients and stress and, in metazoans, growth factors. Mammalian TOR complex 1 (mTORC1) and mTORC2 exert their actions by regulating other important kinases, such as S6 kinase (S6K) and Akt. In the past few years, a significant advance in our understanding of the regulation and functions of mTOR has revealed the crucial involvement of this signalling pathway in the onset and progression of diabetes, cancer and ageing.

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          Author and article information

          Journal
          Nature Reviews Molecular Cell Biology
          Nat Rev Mol Cell Biol
          Springer Science and Business Media LLC
          1471-0072
          1471-0080
          January 2011
          December 15 2010
          January 2011
          : 12
          : 1
          : 21-35
          Article
          10.1038/nrm3025
          3390257
          21157483
          21768b88-87c7-49fa-abb8-ffcc91396c36
          © 2011

          http://www.springer.com/tdm

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