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      Pulmonary pathology of early phase 2019 novel coronavirus (COVID-19) pneumonia in two patients with lung cancer

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          Abstract

          There is currently a lack of pathologic data on the novel coronavirus (SARS-CoV-2) pneumonia, or COVID-19, from autopsy or biopsy. Two patients who recently underwent lung lobectomies for adenocarcinoma were retrospectively found to have had COVID-19 at the time of surgery. These two cases thus provide important first opportunities to study the pathology of COVID-19. Pathologic examinations revealed that, apart from the tumors, the lungs of both patients exhibited edema, proteinaceous exudate, focal reactive hyperplasia of pneumocytes with patchy inflammatory cellular infiltration, and multinucleated giant cells. Hyaline membranes were not prominent. Since both patients did not exhibit symptoms of pneumonia at the time of surgery, these changes likely represent an early phase of the lung pathology of COVID-19 pneumonia.

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          Author and article information

          Contributors
          Journal
          J Thorac Oncol
          J Thorac Oncol
          Journal of Thoracic Oncology
          International Association for the Study of Lung Cancer. Published by Elsevier Inc.
          1556-0864
          1556-1380
          28 February 2020
          28 February 2020
          :
          Affiliations
          [1 ]Department of Pathology, Zhongnan Hospital of Wuhan University, Wuhan, China
          [2 ]Department of Thoracic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, China
          [3 ]Department of Radiology, Zhongnan Hospital of Wuhan University, Wuhan, China
          [4 ]Department of Pathology, University of Chicago Medicine, Chicago, IL 60637
          Author notes
          [∗∗ ]Corresponding author Shu-Yuan Xiao, MD UChicago Medicine 5840 S Maryland Ave Chicago, 60637 UNITED STATES 7737021614 syxiao@ 123456uchicago.edu
          [∗]

          These authors contributed equally to the paper

          Article
          S1556-0864(20)30132-5
          10.1016/j.jtho.2020.02.010
          7128866
          32114094
          2189c4af-a9fa-4794-befe-210bc28f098b
          © 2020 International Association for the Study of Lung Cancer. Published by Elsevier Inc. All rights reserved.

          Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

          History
          : 18 February 2020
          : 20 February 2020
          : 20 February 2020
          Categories
          Article

          coronavirus,covid-19 pneumonia,pathology,sars-cov-2
          coronavirus, covid-19 pneumonia, pathology, sars-cov-2

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