9
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Validation of a new instrument for assessing attitudes on psychedelics in the general population

      research-article

      Read this article at

      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Although there is research interest to assess attitudes on psychedelics, no validated instrument exists for this purpose. We aimed to develop and examine the psychometric properties of the Attitudes on Psychedelics Questionnaire (APQ) in a sample of the Croatian general population. A cross-sectional, web-based survey among the general population was conducted on 1153 participants (62.1% female, 77.7% with a graduate or high school degree, 15.1% health care workers). We assessed participants’ ability to recognize psychedelic substances using a short knowledge test. The APQ consists of 20 items with four sub-scales: Legal Use of Psychedelics, Effects of Psychedelics, Risk Assessment of Psychedelics, and Openness to Psychedelics. This model demonstrated best fit in a confirmatory factor analysis. Total scale reliability was excellent (McDonald’s ω = 0.949, 95% CI = 0.944–0.953). A strong correlation with a similar unvalidated measure (r = 0.885, P < 0.001) demonstrated convergent validity. We observed an association between attitudes and knowledge on psychedelics (r = 0.494, P < 0.001). Younger age, male gender, and lower educational status were associated with higher APQ scores. The APQ is valid, reliable, and could be applied in assessing educational interventions, patients’ treatment outcomes, and the attitudes of different groups of experts. We encourage further validation of the APQ in English.

          Related collections

          Most cited references48

          • Record: found
          • Abstract: not found
          • Article: not found

          Cutoff criteria for fit indexes in covariance structure analysis: Conventional criteria versus new alternatives

            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Unskilled and unaware of it: how difficulties in recognizing one's own incompetence lead to inflated self-assessments.

            People tend to hold overly favorable views of their abilities in many social and intellectual domains. The authors suggest that this overestimation occurs, in part, because people who are unskilled in these domains suffer a dual burden: Not only do these people reach erroneous conclusions and make unfortunate choices, but their incompetence robs them of the metacognitive ability to realize it. Across 4 studies, the authors found that participants scoring in the bottom quartile on tests of humor, grammar, and logic grossly overestimated their test performance and ability. Although their test scores put them in the 12th percentile, they estimated themselves to be in the 62nd. Several analyses linked this miscalibration to deficits in metacognitive skill, or the capacity to distinguish accuracy from error. Paradoxically, improving the skills of participants, and thus increasing their metacognitive competence, helped them recognize the limitations of their abilities.
              Bookmark
              • Record: found
              • Abstract: found
              • Article: found
              Is Open Access

              MDMA-assisted therapy for severe PTSD: a randomized, double-blind, placebo-controlled phase 3 study

              Post-traumatic stress disorder (PTSD) presents a major public health problem for which currently available treatments are modestly effective. We report the findings of a randomized, double-blind, placebo-controlled, multi-site phase 3 clinical trial (NCT03537014) to test the efficacy and safety of 3,4-methylenedioxymethamphetamine (MDMA)-assisted therapy for the treatment of patients with severe PTSD, including those with common comorbidities such as dissociation, depression, a history of alcohol and substance use disorders, and childhood trauma. After psychiatric medication washout, participants ( n  = 90) were randomized 1:1 to receive manualized therapy with MDMA or with placebo, combined with three preparatory and nine integrative therapy sessions. PTSD symptoms, measured with the Clinician-Administered PTSD Scale for DSM-5 (CAPS-5, the primary endpoint), and functional impairment, measured with the Sheehan Disability Scale (SDS, the secondary endpoint) were assessed at baseline and at 2 months after the last experimental session. Adverse events and suicidality were tracked throughout the study. MDMA was found to induce significant and robust attenuation in CAPS-5 score compared with placebo ( P  < 0.0001, d  = 0.91) and to significantly decrease the SDS total score ( P  = 0.0116, d  = 0.43). The mean change in CAPS-5 scores in participants completing treatment was −24.4 (s.d. 11.6) in the MDMA group and −13.9 (s.d. 11.5) in the placebo group. MDMA did not induce adverse events of abuse potential, suicidality or QT prolongation. These data indicate that, compared with manualized therapy with inactive placebo, MDMA-assisted therapy is highly efficacious in individuals with severe PTSD, and treatment is safe and well-tolerated, even in those with comorbidities. We conclude that MDMA-assisted therapy represents a potential breakthrough treatment that merits expedited clinical evaluation. Results from a phase 3, double-blind, randomized, placebo-controlled trial demonstrate that MDMA-assisted therapy is safe and effective in treating severe post-traumatic stress disorder.
                Bookmark

                Author and article information

                Contributors
                marija.franka.zuljevic@mefst.hr
                Journal
                Sci Rep
                Sci Rep
                Scientific Reports
                Nature Publishing Group UK (London )
                2045-2322
                29 October 2022
                29 October 2022
                2022
                : 12
                : 18225
                Affiliations
                [1 ]GRID grid.38603.3e, ISNI 0000 0004 0644 1675, Department of Medical Humanities, School of Medicine, , University of Split, ; Šoltanska 2, 21000 Split, Croatia
                [2 ]GRID grid.38603.3e, ISNI 0000 0004 0644 1675, Department of Research in Biomedicine and Health, School of Medicine, , University of Split, ; Split, Croatia
                [3 ]GRID grid.38603.3e, ISNI 0000 0004 0644 1675, Department of Psychology, Faculty of Humanities and Social Sciences, , University of Split, ; Split, Croatia
                [4 ]GRID grid.38603.3e, ISNI 0000 0004 0644 1675, School of Medicine, , University of Split, ; Split, Croatia
                [5 ]GRID grid.412721.3, ISNI 0000 0004 0366 9017, Department of Psychiatry, , University Hospital Centre Split, ; Split, Croatia
                Author information
                http://orcid.org/0000-0001-9805-7491
                http://orcid.org/0000-0002-8719-7277
                http://orcid.org/0000-0002-8577-056X
                http://orcid.org/0000-0002-1748-7586
                http://orcid.org/0000-0001-6465-6568
                http://orcid.org/0000-0003-1681-0780
                Article
                23056
                10.1038/s41598-022-23056-5
                9617880
                36309539
                2199006e-c069-4728-bd01-f3d643571e05
                © The Author(s) 2022

                Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

                History
                : 29 July 2022
                : 25 October 2022
                Funding
                Funded by: FundRef http://dx.doi.org/10.13039/501100004488, Hrvatska Zaklada za Znanost;
                Award ID: IP-2019-04-4882
                Award Recipient :
                Categories
                Article
                Custom metadata
                © The Author(s) 2022

                Uncategorized
                medical research,psychology
                Uncategorized
                medical research, psychology

                Comments

                Comment on this article