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High-mobility group box-1 in ischemia-reperfusion injury of the heart.
Martin Andrassy
1 ,
Hans C Volz ,
John C Igwe ,
Benjamin Funke ,
Sebastian N Eichberger ,
Ziya Kaya ,
Sebastian Buss ,
Frank Autschbach ,
Sven T Pleger ,
Ivan K Lukic ,
Florian Bea ,
Stefan E Hardt ,
Per M Humpert ,
Marco E Bianchi ,
Heimo Mairbäurl ,
Peter P Nawroth ,
Andrew Remppis ,
Hugo A Katus ,
Angelika Bierhaus
Jun 24 2008
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Abstract
High-mobility group box-1 (HMGB1) is a nuclear factor released by necrotic cells and by activated immune cells. HMGB1 signals via members of the toll-like receptor family and the receptor for advanced glycation end products (RAGE). Although HMGB1 has been implicated in ischemia/reperfusion (I/R) injury of the liver and lung, its role in I/R injury of the heart remains unclear.