Association between RTEL1 gene polymorphisms and COPD susceptibility in a Chinese Han population

Abstract

Objective

We investigated the association between single-nucleotide polymorphisms in regulation of telomere elongation helicase 1 ( RTEL1), which has been associated with telomere length in several brain cancers and age-related diseases, and the risk of chronic obstructive pulmonary disease (COPD) in a Chinese Han population.

Methods

In a case–control study that included 279 COPD cases and 290 healthy controls, five single-nucleotide polymorphisms in RTEL1 were selected and genotyped using the Sequenom MassARRAY platform. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using unconditional logistic regression after adjusting for age and gender.

Results

In the genotype model analysis, we determined that rs4809324 polymorphism had a decreased effect on the risk of COPD (CC versus TT: OR =0.28; 95% CI =0.10–0.82; P=0.02). In the genetic model analysis, we found that the “C/C” genotype of rs4809324 was associated with a decreased risk of COPD based on the codominant model (OR =0.33; 95% CI =0.13–0.86; P=0.022) and recessive model (OR =0.32; 95% CI =0.12–0.80; P=0.009).

Conclusion

Our data shed new light on the association between genetic polymorphisms of RTEL1 and COPD susceptibility in the Chinese Han population.

Journal

Journal ID (nlm-ta): Int J Chron Obstruct Pulmon Dis

Journal ID (iso-abbrev): Int J Chron Obstruct Pulmon Dis

Journal ID (publisher-id): International Journal of COPD

Title: International Journal of Chronic Obstructive Pulmonary Disease

Publisher: Dove Medical Press

ISSN (Print): 1176-9106

ISSN (Electronic): 1178-2005

Publication date Collection: 2017

Publication date (Electronic): 17 March 2017

Volume: 12

Pages: 931-936

Affiliations

Department of Emergency, People’s Hospital of Hainan Province, Haikou, Hainan, People’s Republic of China

Author notes

Correspondence: Yipeng Ding, Department of Emergency, People’s Hospital of Hainan Province, 19 Xiuhua Road, Haikou, Hainan, 570311, People’s Republic of China, Tel/fax [phone], Email dryipengding@ 123456163.com

[*]

These authors contributed equally to this work

Article

Publisher ID: copd-12-931

DOI: 10.2147/COPD.S131246

PMC ID: 5364006

Copyright statement: © 2017 Ding et al. This work is published and licensed by Dove Medical Press Limited

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Categories

Subject: Original Research