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      A Novel Silk Fiber–Based Scaffold for Regeneration of the Anterior Cruciate Ligament : Histological Results From a Study in Sheep

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          Abstract

          Because of ongoing problems with anterior cruciate ligament (ACL) reconstruction, new approaches in the treatment of ACL injuries, particularly strategies based on tissue engineering, have gained increasing research interest. To allow for ACL regeneration, a structured scaffold that provides a mechanical basis, has cells from different sources, and comprises mechanical as well as biological factors is needed. Biological materials, biodegradable polymers, and composite materials are being used and tested as scaffolds. The optimal scaffold for ACL regeneration should be biocompatible and biodegradable to allow tissue ingrowth but also needs to have the right mechanical properties to provide immediate mechanical stability.

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          Multi-resolution, object-oriented fuzzy analysis of remote sensing data for GIS-ready information

          Ursula Benz, Wolf Hofmann, Gregor Willhauck … (2004)
          Article 0 comments Cited 421 times – based on 0 reviews     Review now
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            Biodegradation of Silk Biomaterials

            Yang Cao, Bochu Wang (2009)
            Silk fibroin from the silkworm, Bombyx mori, has excellent properties such as biocompatibility, biodegradation, non-toxicity, adsorption properties, etc. As a kind of ideal biomaterial, silk fibroin has been widely used since it was first utilized for sutures a long time ago. The degradation behavior of silk biomaterials is obviously important for medical applications. This article will focus on silk-based biomaterials and review the degradation behaviors of silk materials.
            Article 0 comments Cited 153 times – based on 0 reviews     Review now
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              Allograft Versus Autograft Anterior Cruciate Ligament Reconstruction

              Christopher Kaeding, Brian Aros, Angela D. Pedroza … (2011)
              Background: Tearing an anterior cruciate ligament (ACL) graft is a devastating occurrence after ACL reconstruction (ACLR). Identifying and understanding the independent predictors of ACLR graft failure is important for surgical planning, patient counseling, and efforts to decrease the risk of graft failure. Hypothesis: Patient and surgical variables will predict graft failure after ACLR. Study Design: Prospective cohort study. Methods: A multicenter group initiated a cohort study in 2002 to identify predictors of ACLR outcomes, including graft failure. First, to control for confounders, a single surgeon’s data (n = 281 ACLRs) were used to develop a multivariable regression model for ACLR graft failure. Evaluated variables were graft type (autograft vs allograft), sex, age, body mass index, activity at index injury, presence of a meniscus tear, and primary versus revision reconstruction. Second, the model was validated with the rest of the multicenter study’s data (n = 645 ACLRs) to evaluate the generalizability of the model. Results: Patient age and ACL graft type were significant predictors of graft failure for all study surgeons. Patients in the age group of 10 to 19 years had the highest percentage of graft failures. The odds of graft rupture with an allograft reconstruction are 4 times higher than those of autograft reconstructions. For each 10-year decrease in age, the odds of graft rupture increase 2.3 times. Conclusion: There is an increased risk of ACL graft rupture in patients who have undergone allograft reconstruction. Younger patients also have an increased risk of ACL graft failure. Clinical Relevance: Given these risks for ACL graft rupture, allograft ACLRs should be performed with caution in the younger patient population.
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                Author and article information

                Journal
                Title: The American Journal of Sports Medicine
                Abbreviated Title: Am J Sports Med
                Publisher: SAGE Publications
                ISSN (Print): 0363-5465
                ISSN (Electronic): 1552-3365
                Publication date Created: June 2016
                Publication date Created: June 2016
                Publication date (Electronic): March 08 2016
                Publication date (Print): June 2016
                Volume: 44
                Issue: 6
                Pages: 1547-1557
                Affiliations
                [1 ]Department of Biochemical Engineering, University of Applied Sciences Technikum Wien, Vienna, Austria
                [2 ]Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, AUVA Research Center, Vienna, Austria
                [3 ]Austrian Cluster for Tissue Regeneration, Vienna, Austria
                [4 ]Karl Donath Laboratory for Hard Tissue and Biomaterial Research, Medical University of Vienna, Vienna, Austria
                [5 ]Department of Traumatology, Medical University of Vienna, Vienna, Austria
                [6 ]Department of Experimental Trauma Surgery, Technical University of Munich, Munich, Germany
                Article
                DOI: 10.1177/0363546516631954
                PubMed ID: 26957219
                SO-VID: 21bd9bc3-84d0-4b0d-9d67-1c7add8aa434
                Copyright © © 2016
                License:

                http://journals.sagepub.com/page/policies/text-and-data-mining-license

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