3
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Preferential Coupling of the NAADP Pathway to Exocytosis in T-Cells.

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          A cytotoxic T-lymphocyte (CTL) kills an infected or tumorigenic cell by Ca2+-dependent exocytosis of cytolytic granules at the immunological synapse formed between the two cells. However, these granules are more than reservoirs of secretory cytolytic proteins but may also serve as unique Ca2+ signaling hubs that autonomously generate their own signals for exocytosis. This review discusses a selective role for the Ca2+-mobilizing messenger, nicotinic acid adenine dinucleotide phosphate (NAADP) and its molecular targets, two-pore channels (TPCs), in stimulating exocytosis. Given that TPCs reside on the exocytotic granules themselves, these vesicles generate as well as respond to NAADP-dependent Ca2+ signals, which may have wider implications for stimulus-secretion coupling, vesicular fusion, and patho-physiology.

          Related collections

          Author and article information

          Journal
          Messenger (Los Angel)
          Messenger (Los Angeles, Calif. : Print)
          American Scientific Publishers
          2167-955X
          Jun 2015
          : 4
          : 1
          Affiliations
          [1 ] Department of Pharmacology, University of Oxford, Oxford, OX1 3QT, UK.
          Article
          EMS68702
          10.1166/msr.2015.1040
          4910867
          27330870
          21c8a61d-9e4a-4cbb-8d76-649aabd2826c
          History

          Exocytosis,CTL,Ca2+,Cytolytic Granule,Lysosomes,NAADP,T-Lymphocyte,TPC
          Exocytosis, CTL, Ca2+, Cytolytic Granule, Lysosomes, NAADP, T-Lymphocyte, TPC

          Comments

          Comment on this article