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      Multiple alignment of DNA sequences with MAFFT.

      Methods in Molecular Biology (Clifton, N.j.)

      Software, methods, Sequence Analysis, DNA, Sequence Alignment, Molecular Sequence Data, Humans, Computational Biology, Base Sequence, Animals, Algorithms

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          Abstract

          Multiple alignment of DNA sequences is an important step in various molecular biological analyses. As a large amount of sequence data is becoming available through genome and other large-scale sequencing projects, scalability, as well as accuracy, is currently required for a multiple sequence alignment (MSA) program. In this chapter, we outline the algorithms of an MSA program MAFFT and provide practical advice, focusing on several typical situations a biologist sometimes faces. For genome alignment, which is beyond the scope of MAFFT, we introduce two tools: TBA and MAUVE.

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          Journal
          10.1007/978-1-59745-251-9_3
          19378139

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