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      Multiple alignment of DNA sequences with MAFFT.

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          Abstract

          Multiple alignment of DNA sequences is an important step in various molecular biological analyses. As a large amount of sequence data is becoming available through genome and other large-scale sequencing projects, scalability, as well as accuracy, is currently required for a multiple sequence alignment (MSA) program. In this chapter, we outline the algorithms of an MSA program MAFFT and provide practical advice, focusing on several typical situations a biologist sometimes faces. For genome alignment, which is beyond the scope of MAFFT, we introduce two tools: TBA and MAUVE.

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          Author and article information

          Journal
          Methods Mol Biol
          Methods in molecular biology (Clifton, N.J.)
          Springer Science and Business Media LLC
          1064-3745
          1064-3745
          2009
          : 537
          Affiliations
          [1 ] Digital Medicine Initiative, Kyushu University, Fukuoka, Japan.
          Article
          10.1007/978-1-59745-251-9_3
          19378139
          21cbf06b-8995-47b1-9aaf-842504c17d2b
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