12
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Chronic myeloid leukaemia as a model of disease evolution in human cancer.

      Nature reviews. Cancer

      Animals, Blast Crisis, Cell Differentiation, Disease Progression, Fusion Proteins, bcr-abl, physiology, Gene Expression Profiling, Genes, Tumor Suppressor, Genomic Instability, Humans, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, genetics, pathology, Models, Biological, Neoplasms

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Chronic myeloid leukaemia (CML) can be considered as a paradigm for neoplasias that evolve through a multi-step process. CML is also one of the best examples of a disease that can be targeted by molecular therapy; however, the success of new 'designer drugs' is largely restricted to the chronic phase of the disease. If not cured at this stage, CML invariably progresses and transforms into an acute-type leukaemia undergoing a 'blast crisis'. The causes of this transformation are still poorly understood. What mechanisms underlie this progression, and are they shared by other common cancers?

          Related collections

          Author and article information

          Journal
          17522713
          10.1038/nrc2147

          Comments

          Comment on this article