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      Renal Tubular Hypouricemia: Evidence for Defect of Both Secretion and Reabsorption

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          Abstract

          Two patients had hypouricemia due to increased uric acid clearance. They showed no decrease of urate clearance to creatinine clearance ratio (C<sub>ua</sub>/C<sub>cr</sub>) following pyrazinamide administration, and no increase of C<sub>ua</sub>/C<sub>cr </sub>after probenecid. One patient showed a limited decline in C<sub>ua</sub>/C<sub>cr</sub>after intravenous furosemide. In the other patient, neither acetylsalicylate nor furosemide produced any noticeable change in C<sub>ua</sub>/C<sub>cr</sub>. Both showed a normal diuretic response after intravenous furosemide. The results indicate that they had massive defects in urate transport along the nephron, probably including both secretion and reabsorption.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1990
          1990
          10 December 2008
          : 56
          : 4
          : 421-426
          Affiliations
          Second Department of Internal Medicine, Tokyo Medical and Dental University, Kidney Center, Tokyo Metropolitan Ookubo Hospital, Tokyo, and Department of Internal Medicine, Toride Kyodo Hospital, Ibaraki, Japan
          Article
          186187 Nephron 1990;56:421–426
          10.1159/000186187
          2080002
          © 1990 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 6
          Categories
          Case Report

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