Angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers in patients with abdominal aortic aneurysms: nation-wide cohort study.

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Abstract

The renin-angiotensin system is thought to play a pivotal role in the pathogenesis of abdominal aortic aneurysms (AAAs). However, effects of angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin II type 1 receptor blockers (ARBs) on human AAAs remain unclear. We therefore examined whether treatment with ACEIs or ARBs influenced hard clinical end points in a nation-wide cohort of patients with AAA.

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Journal ID (iso-abbrev): Arterioscler. Thromb. Vasc. Biol.

Title: Arteriosclerosis, thrombosis, and vascular biology

Publisher: Ovid Technologies (Wolters Kluwer Health)

ISSN (Electronic): 1524-4636

ISSN (Print): 1079-5642

Publication date (Electronic): Mar 2015

Volume: 35

Issue: 3

Affiliations

[1 ] From the Department of Cardiology, Gentofte University Hospital, Hellerup, Denmark (K.E.K., G.H.G., P.R.H.); Institute of Health, Science and Technology, Aalborg University, Aalborg, Denmark (C.T.-P.); The National Institute of Public Health, University of Southern Denmark, Odense, Denmark (G.H.G.); Department of Nephrology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark (M.E.); and Institute of Biological Psychiatry, Mental Health Centre Sct. Hans, Copenhagen University Hospital, Roskilde, Denmark (H.B.R.). karl.emil.kristensen@regionh.dk.

[2 ] From the Department of Cardiology, Gentofte University Hospital, Hellerup, Denmark (K.E.K., G.H.G., P.R.H.); Institute of Health, Science and Technology, Aalborg University, Aalborg, Denmark (C.T.-P.); The National Institute of Public Health, University of Southern Denmark, Odense, Denmark (G.H.G.); Department of Nephrology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark (M.E.); and Institute of Biological Psychiatry, Mental Health Centre Sct. Hans, Copenhagen University Hospital, Roskilde, Denmark (H.B.R.).

Article

Publisher Item ID: ATVBAHA.114.304428

DOI: 10.1161/ATVBAHA.114.304428

PubMed ID: 25633315

SO-VID: 22001152-8b03-4680-8b46-648eec98060b

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Keywords: aneurysm,cardiovascular diseases,hypertension,pharmacoepidemiology,renin-angiotensin system

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Keywords: aneurysm, cardiovascular diseases, hypertension, pharmacoepidemiology, renin-angiotensin system

Angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers in patients with abdominal aortic aneurysms: nation-wide cohort study.

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