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      Pyogenic granuloma of the oral cavity: comparative study of its clinicopathological and immunohistochemical features.

      Pathology International
      Actins, analysis, Adolescent, Adult, Aged, Antigens, CD34, Blood Vessels, pathology, Child, Female, Gingiva, Granuloma, Pyogenic, classification, metabolism, Humans, Immunohistochemistry, Lip, Male, Middle Aged, Mouth Diseases, Mouth Mucosa, Muscles, chemistry, Tongue

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          There are two histological types of pyogenic granuloma (PG) of the oral cavity: the lobular capillary hemangioma (LCH) and non-LCH type. The aim of the present study was to examine and compare the clinical features, etiological factors, diameter of vascular elements and immunohistochemical features of LCH and non-LCH histological types of PG to determine whether they are two distinct entities. Thirty cases of LCH and 26 cases of non-LCH PG were retrieved and retrospectively studied. Clinically, LCH PG occurred more frequently (66.4%) as sessile lesion whereas non-LCH PG occurred as pedunculated (77%). Non-LCH PG was associated more frequently (86.4%) with etiological factors. The lobular area of the LCH PG contained a greater number of blood vessels with small luminal diameter than did the central area of non-LCH PG. In the central area of non-LCH PG a significantly greater number of vessels with perivascular mesenchymal cells non-reactive for alpha-smooth muscle actin and muscle-specific actin was present than in the lobular area of LCH PG. The differences found in the present study suggest that the two histological types of PG represent distinct entities.

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