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      Hospital readmission within 10 years post stroke: frequency, type and timing

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          Abstract

          Background

          The aim of this study was to examine the hospital readmissions in a 10 year follow-up of a stroke cohort previously studied for acute and subacute complications and to focus on their frequency, their causes and their timing.

          Methods

          The hospital records of 243 patients, 50% of a cohort of 489 patients acutely and consecutively admitted to our stroke unit in 2002/3, were subjected to review 10 years after the incidental stroke and all acute admissions were examined. The main admitting diagnoses were attributed to one of 18 predefined categories of illness. Additionally, the occurrence of death was registered.

          Results

          After 10 years 68.9% of patients had died and 72.4% had been readmitted to the hospital with a mean number of readmissions of 3.4 (+15.1 SD). 20% of the readmissions were due to a vascular cause, 17.3% were caused by infection, 9.3% by falls with (6.1%) and without fracture, 5.7% by a hemorrhagic event. The readmission rate was highest in the first 6 months post stroke with a rate of 116.2 admissions/100 live patient-years. Falls with fractures occurred maximally 3–5 years post stroke.

          Conclusions

          Hospital readmissions over the 10 years following stroke are caused by vascular events, infections, falls and hemorrhagic events, where the first 6 months are a period of particular vulnerability. The magnitude and the spectrum of these long-term complications suggest the need for a more comprehensive approach to post stroke prophylaxis.

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          Most cited references20

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          Change in stroke incidence, mortality, case-fatality, severity, and risk factors in Oxfordshire, UK from 1981 to 2004 (Oxford Vascular Study).

          The incidence of stroke is predicted to rise because of the rapidly ageing population. However, over the past two decades, findings of randomised trials have identified several interventions that are effective in prevention of stroke. Reliable data on time-trends in stroke incidence, major risk factors, and use of preventive treatments in an ageing population are required to ascertain whether implementation of preventive strategies can offset the predicted rise in stroke incidence. We aimed to obtain these data. We ascertained changes in incidence of transient ischaemic attack and stroke, risk factors, and premorbid use of preventive treatments from 1981-84 (Oxford Community Stroke Project; OCSP) to 2002-04 (Oxford Vascular Study; OXVASC). Of 476 patients with transient ischaemic attacks or strokes in OXVASC, 262 strokes and 93 transient ischaemic attacks were incident events. Despite more complete case-ascertainment than in OCSP, age-adjusted and sex-adjusted incidence of first-ever stroke fell by 29% (relative incidence 0.71, 95% CI 0.61-0.83, p=0.0002). Incidence declined by more than 50% for primary intracerebral haemorrhage (0.47, 0.27-0.83, p=0.01) but was unchanged for subarachnoid haemorrhage (0.83, 0.44-1.57, p=0.57). Thus, although 28% more incident strokes (366 vs 286) were expected in OXVASC due to demographic change alone (33% increase in those aged 75 or older), the observed number fell (262 vs 286). Major reductions were recorded in mortality rates for incident stroke (0.63, 0.44-0.90, p=0.02) and in incidence of disabling or fatal stroke (0.60, 0.50-0.73, p<0.0001), but no change was seen in case-fatality due to incident stroke (17.2% vs 17.8%; age and sex adjusted relative risk 0.85, 95% CI 0.57-1.28, p=0.45). Comparison of premorbid risk factors revealed substantial reductions in the proportion of smokers, mean total cholesterol, and mean systolic and diastolic blood pressures and major increases in premorbid treatment with antiplatelet, lipid-lowering, and blood pressure lowering drugs (all p<0.0001). The age-specific incidence of major stroke in Oxfordshire has fallen by 40% over the past 20 years in association with increased use of preventive treatments and major reductions in premorbid risk factors.
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            Cerebral vascular accidents in patients over the age of 60. II. Prognosis.

            J. Rankin (1957)
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              An International Standard Set of Patient-Centered Outcome Measures After Stroke

              Supplemental Digital Content is available in the text.
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                Author and article information

                Contributors
                +47-72575495 , gitta.rohweder@ntnu.no
                oyvind.salvesen@ntnu.no
                hanne.ellekjer@stolav.no
                bent.indredavik@ntnu.no
                Journal
                BMC Neurol
                BMC Neurol
                BMC Neurology
                BioMed Central (London )
                1471-2377
                19 June 2017
                19 June 2017
                2017
                : 17
                : 116
                Affiliations
                [1 ]ISNI 0000 0004 0627 3560, GRID grid.52522.32, From the Stroke Unit, Department of Internal Medicine, , St Olav’s Hospital, University Hospital of Trondheim, ; Harald Hardraades gate 5, 7030 Trondheim, Norway
                [2 ]ISNI 0000 0001 1516 2393, GRID grid.5947.f, The Institute for Neuromedicine (INM), Faculty of Medicine and Health Sciences, , Norwegian University of Science And Technology (NTNU), ; Trondheim, Norway
                [3 ]ISNI 0000 0001 1516 2393, GRID grid.5947.f, The Unit of Applied Clinical Research, Faculty of Medicine and Health Sciences, , Norwegian University of Science And Technology (NTNU), ; Trondheim, Norway
                Author information
                http://orcid.org/0000-0003-2237-3927
                Article
                897
                10.1186/s12883-017-0897-z
                5477341
                28629340
                220b4178-4741-4ca5-a842-d5c059c99af0
                © The Author(s). 2017

                Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License ( http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver ( http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

                History
                : 6 February 2017
                : 12 June 2017
                Funding
                Funded by: Regional Health Service Central Norway
                Funded by: FundRef http://dx.doi.org/10.13039/100009123, Norges Teknisk-Naturvitenskapelige Universitet;
                Categories
                Research Article
                Custom metadata
                © The Author(s) 2017

                Neurology
                stroke,readmission,readmission rate,longterm follow-up,secondary prophylaxis
                Neurology
                stroke, readmission, readmission rate, longterm follow-up, secondary prophylaxis

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