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      Growth Hormone Deficiency (GHD) from Birth to 2 Years of Age: Diagnostic Specifics of GHD during the Early Phase of Life

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          Abstract

          The first 2 years of life represent a transition period when growth changes from predominantly growth hormone (GH) independent to GH dependent. In the fetus, growth is influenced by genetic and environmental factors in addition to nutrition and growth factors including insulin. In infancy, nutrition remains an important determinant of growth. GH levels are high in mid-gestation and at birth, then fall sharply for the first few weeks and more slowly over the next few months reaching pre-pubertal levels by around the age of 6 months. GH deficiency (GHD) may present at birth with hypoglycaemia, micropenis or prolonged conjugated hyperbilirubinaemia. Although length at birth is usually within the normal centile ranges, post-natal growth failure can begin early and be profound.

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          Most cited references 12

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          Intrauterine growth retardation and postnatal growth failure associated with deletion of the insulin-like growth factor I gene.

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            Consensus Guidelines for the Diagnosis and Treatment of Growth Hormone (GH) Deficiency in Childhood and Adolescence: Summary Statement of the GH Research Society

             G. Society (2000)
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              Insulin-like growth factors and their binding proteins in the term and preterm human fetus and neonate with normal and extremes of intrauterine growth

               L C Giudice (1995)
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                Author and article information

                Journal
                HRE
                Horm Res Paediatr
                10.1159/issn.1663-2818
                Hormone Research in Paediatrics
                S. Karger AG
                978-3-8055-7609-3
                978-3-318-00998-9
                1663-2818
                1663-2826
                2003
                July 2003
                17 November 2004
                : 60
                : Suppl 1
                : 2-9
                Affiliations
                Rosie Hospital, Addenbrooke’s NHS Trust, Cambridge, UK
                Article
                71219 Horm Res 2003;60(suppl 1):2–9
                10.1159/000071219
                12955011
                © 2003 S. Karger AG, Basel

                Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

                Page count
                Figures: 1, Tables: 1, References: 86, Pages: 8
                Categories
                GHD from Birth to 2 Years of Age

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