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      Growth Hormone Deficiency (GHD) from Birth to 2 Years of Age: Diagnostic Specifics of GHD during the Early Phase of Life

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          The first 2 years of life represent a transition period when growth changes from predominantly growth hormone (GH) independent to GH dependent. In the fetus, growth is influenced by genetic and environmental factors in addition to nutrition and growth factors including insulin. In infancy, nutrition remains an important determinant of growth. GH levels are high in mid-gestation and at birth, then fall sharply for the first few weeks and more slowly over the next few months reaching pre-pubertal levels by around the age of 6 months. GH deficiency (GHD) may present at birth with hypoglycaemia, micropenis or prolonged conjugated hyperbilirubinaemia. Although length at birth is usually within the normal centile ranges, post-natal growth failure can begin early and be profound.

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          Most cited references 12

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          Intrauterine growth retardation and postnatal growth failure associated with deletion of the insulin-like growth factor I gene.

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            Consensus Guidelines for the Diagnosis and Treatment of Growth Hormone (GH) Deficiency in Childhood and Adolescence: Summary Statement of the GH Research Society

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              Insulin-like growth factors and their binding proteins in the term and preterm human fetus and neonate with normal and extremes of intrauterine growth

               L C Giudice (1995)

                Author and article information

                Horm Res Paediatr
                Hormone Research in Paediatrics
                S. Karger AG
                July 2003
                17 November 2004
                : 60
                : Suppl 1
                : 2-9
                Rosie Hospital, Addenbrooke’s NHS Trust, Cambridge, UK
                71219 Horm Res 2003;60(suppl 1):2–9
                © 2003 S. Karger AG, Basel

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                Page count
                Figures: 1, Tables: 1, References: 86, Pages: 8
                GHD from Birth to 2 Years of Age


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