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      miR-98 suppresses tumor cell growth and metastasis by targeting IGF1R in oral squamous cell carcinoma.

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          Abstract

          Increasing evidences indicate that dysregulation of miRNAs contributes to the pathogenesis of oral squamous cell carcinoma (OSCC). However, little is known about the potential role of miR-98 in OSCC. Here, we found that miR-98 was downregulated in OSCC tissues and cell lines. Overexpression of miR-98 inhibited proliferation, colony formation, migration, and invasion of OSCC cells. IGF1R was identified as the potential target of miR-98 using dual luciferase assay, qRT-PCR and western blot. Furthermore, restoration of IGF1R remarkably reversed the tumor-suppressive effects of miR-98 on OSCC cells. Moreover, miR-98 expression was inversely correlated with IGF1R expression in 19 cases of OSCC. These findings suggest that miR-98 inhibits cancer cell growth and metastasis by direct targeting IGF1R, implicating miR-98 as a novel potential therapeutic target for OSCC.

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          Author and article information

          Journal
          Int J Clin Exp Pathol
          International journal of clinical and experimental pathology
          1936-2625
          1936-2625
          2015
          : 8
          : 10
          Affiliations
          [1 ] Department of Endodontics, School and Hospital of Stomatology, Wenzhou Medical University Wenzhou, 325000, PR China.
          [2 ] Department of Gastroenterology, Jining NO.1 People's Hospital Jining, Shandong, 272011, PR China.
          [3 ] Department of Stomatology, Second Hospital of Tianjin Medical University Tianjin, 300211, PR China.
          Article
          4680355
          26722410

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