Concentration of fractional excretion of nitric oxide (FENO): A potential airway biomarker of restored CFTR function.

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Abstract

Lower airway biomarkers of restored cystic fibrosis transmembrane conductance regulator (CFTR) function are limited. We hypothesized that fractional excretion of nitric oxide (FENO), typically low in CF patients, would demonstrate reproducibility during CFTR-independent therapies, and increase during CFTR-specific intervention (ivacaftor) in patients with CFTR gating mutations.

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Author and article information

Journal

Journal ID (iso-abbrev): J. Cyst. Fibros.

Title: Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society

Publisher: Elsevier BV

ISSN (Electronic): 1873-5010

ISSN (Print): 1569-1993

Publication date (Electronic): Nov 2015

Volume: 14

Issue: 6

Affiliations

[1 ] Department of Pediatrics, Nationwide Children's Hospital, Columbus, OH, United States.

[2 ] Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States.

[3 ] Department of Mathematical Sciences, University of Cincinnati, Cincinnati, OH, United States.

[4 ] Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States. Electronic address: john.clancy@cchmc.org.

Article

Publisher Item ID: S1569-1993(15)00164-2

DOI: 10.1016/j.jcf.2015.07.002

PubMed ID: 26210165

SO-VID: 2224c804-0d3e-4671-8e9f-cc7f4819932c

History

Keywords: Cystic fibrosis,Nitric oxide,CFTR biomarker,CFTR modulator,FENO

Data availability:

Keywords: Cystic fibrosis, Nitric oxide, CFTR biomarker, CFTR modulator, FENO

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