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      Current Research Trends in Traditional Chinese Medicine Formula: A Bibliometric Review from 2000 to 2016

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          Abstract

          Background

          Traditional Chinese Medicine Formula (TCMF) study has been recognized widely by medical scientists around the world. However, few researchers have analyzed and summarized the rapid growth of academic articles of TCMF published in English. The primary aim of this work was to assess the outcome of these research outputs in the TCMF field from 2000 to 2016 and to evaluate the situation and tendency.

          Methods

          Research datasets were acquired from the Web of Science database, which includes all academic articles published from 2000 to 2016; articles were tracked by the keywords “Traditional Chinese Medicine”, “Traditional Chinese Medicine Formula”, and “Chinese herb formula”. Moreover, visualization software CiteSpace V was used to analyze and generate visualization knowledge maps.

          Results

          In total, 26,917 articles appeared in the Web of Science database, and only 2,621 publications met requirement based on reading the abstract or full text. The annual publications total, list of journals, research interests, list of medicine names, disease types, and the top 20 cited articles were given in this research paper. In addition, we compared the research of Japan and Korea TCMF, in the appendix.

          Conclusion

          This review demonstrates that increasingly more researchers have interest in the TCMF and TCMF has great significant advantages over other areas of focus. However, these publications were published rarely in top academic journals and most best-quality papers have bias toward medical analysis rather than pharmacology. To make a breakthrough in TCMF field, further investigation is required to place emphasis on the deepening study of the mechanism of related TCMF.

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          Most cited references28

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          Maternal Depression: A Global Threat to Children’s Health, Development, and Behavior and to Human Rights

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            Chemokines in depression in health and in inflammatory illness: a systematic review and meta-analysis

            Inflammatory illness is associated with depression. Preclinical work has shown that chemokines are linked with peripheral–central crosstalk and may be important in mediating depressive behaviours. We sought to establish what evidence exists that differences in blood or cerebrospinal fluid chemokine concentration discriminate between individuals with depression and those without. Following PRISMA guidelines, we systematically searched Embase, PsycINFO and Medline databases. We included participants with physical illness for subgroup analysis, and excluded participants with comorbid psychiatric diagnoses. Seventy-three studies met the inclusion criteria for the meta-analysis. Individuals with depression had higher levels of blood CXCL4 and CXCL7 and lower levels of blood CCL4. Sensitivity analysis of studies with only physically healthy participants identified higher blood levels of CCL2, CCL3, CCL11, CXCL7 and CXCL8 and lower blood levels of CCL4. All other chemokines examined did not reveal significant differences (blood CCL5, CCL7, CXCL9, CXCL10 and cerebrospinal fluid CXCL8 and CXCL10). Analysis of the clinical utility of the effect size of plasma CXCL8 in healthy individuals found a negative predictive value 93.5%, given the population prevalence of depression of 10%. Overall, our meta-analysis finds evidence linking abnormalities of blood chemokines with depression in humans. Furthermore, we have demonstrated the possibility of classifying individuals with depression based on their inflammatory biomarker profile. Future research should explore putative mechanisms underlying this association, attempt to replicate existing findings in larger populations and aim to develop new diagnostic and therapeutic strategies.
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              Relative indicators and relational charts for comparative assessment of publication output and citation impact

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                Author and article information

                Contributors
                Journal
                Evid Based Complement Alternat Med
                Evid Based Complement Alternat Med
                ECAM
                Evidence-based Complementary and Alternative Medicine : eCAM
                Hindawi
                1741-427X
                1741-4288
                2019
                3 March 2019
                3 March 2019
                : 2019
                : 3961395
                Affiliations
                1Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
                2Research Center of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
                3Key Research Laboratory of Prescription Compatibility among Components, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
                4Tianjin University Library, Tianjin 300072, China
                Author notes

                Academic Editor: Armando Zarrelli

                Author information
                http://orcid.org/0000-0003-0025-7474
                http://orcid.org/0000-0002-4800-5076
                http://orcid.org/0000-0003-4392-3713
                Article
                10.1155/2019/3961395
                6420998
                30941195
                2228d350-0796-40bd-b825-de00123ad200
                Copyright © 2019 Yi-Bing Chen et al.

                This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                : 3 November 2018
                : 13 February 2019
                Funding
                Funded by: National Natural Science Foundation of China
                Award ID: 81741119
                Award ID: 81473542
                Categories
                Review Article

                Complementary & Alternative medicine
                Complementary & Alternative medicine

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