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      Quantitative grading of a human blastocyst: optimal inner cell mass size and shape

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      Fertility and Sterility
      Elsevier BV

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          Abstract

          To investigate the predictive value of quantitative measurements of blastocyst morphology on subsequent implantation rates after transfer. Prospective observational study. Private assisted reproductive technology center. One hundred seventy-four IVF patients receiving transfers of expanded blastocyst-stage embryos on day 5 (n = 112) or day 6 (n = 62) after oocyte retrieval. None. Blastocyst diameter, number of trophectoderm cells, inner cell mass (ICM) size, ICM shape, and implantation and pregnancy rates. Blastocyst diameter and trophectoderm cell numbers were unrelated to implantation rates. Day 5 expanded blastocysts with ICMs of >4,500 microm(2) implanted at a higher rate than did those with smaller ICMs (55% vs. 31%). Day 5 expanded blastocysts with slightly oval ICMs implanted at a higher rate (58%) compared with those with either rounder ICMs (7%) or more elongated ICMs (33%). Implantation rates were highest (71%) for embryos with both optimal ICM size and shape. Pregnancy rates were higher for day 5 transfers of optimally shaped ICMs compared with day 5 transfers of optimally sized ICMs. Quantitative measurements of the inner cell mass are highly indicative of blastocyst implantation potential. Blastocysts with relatively large and/or slightly oval ICMs are more likely to implant than other blastocysts.

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          Author and article information

          Journal
          Fertility and Sterility
          Fertility and Sterility
          Elsevier BV
          00150282
          December 2001
          December 2001
          : 76
          : 6
          : 1157-1167
          Article
          10.1016/S0015-0282(01)02870-9
          11730744
          2247ed49-5a4b-4fd7-866d-b89fe2c6cbc5
          © 2001

          https://www.elsevier.com/tdm/userlicense/1.0/

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