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      Indoleamine 2,3-dioxygenase inhibitors from the Northeastern Pacific Marine Hydroid Garveia annulata.

      Journal of Natural Products
      Animals, Humans, Hydrozoa, chemistry, Indoleamine-Pyrrole 2,3,-Dioxygenase, antagonists & inhibitors, Macrolides, isolation & purification, pharmacokinetics, pharmacology, Marine Biology, Molecular Structure, Naphthoquinones, Pyrones

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          Abstract

          Crude extracts of the marine hydroid Garveia annulata show potent inhibition of indoleamine 2,3-dioxygenase (IDO). Fractionation of the extract led to the identification of the new polyketides annulin C (1), 2-hydroxygarveatin E (4), garveatin E (5), and garvin C (9). Annulins A (2), B (3), and C (1) were found to be submicromolar inhibitors of IDO.

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