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Abstract
Cvt19 is specifically required for the transport of resident vacuolar hydrolases that
utilize the cytoplasm-to-vacuole targeting (Cvt) pathway. Autophagy (Apg) and pexophagy,
processes that use the majority of the same protein components as the Cvt pathway,
do not require Cvt19. Cvt19GFP is localized to punctate structures on or near the
vacuole surface. Cvt19 is a peripheral membrane protein that binds to the precursor
form of the Cvt cargo protein aminopeptidase I (prAPI) and travels to the vacuole
with prAPI. These results suggest that Cvt19 is a receptor protein for prAPI that
allows for the selective transport of this protein by both the Cvt and Apg pathways.