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      Membranous Glomerulonephritis Associated with Renal Cell Carcinoma: Failure to Detect a Nephritogenic Tumor Antigen

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          A 57-year-old man with renal cell carcinoma associated with membranous glomerulonephropathy (MGN) developed a transient amelioration of the nephrotic syndrome after excision of the tumor. We tried to identify a nephritogenic tumor antigen using the immunoblotting technique in this patient with MGN, since previous studies examined the interaction between tumor antigens and IgG eluted from the kidney tissue using immunofluorescence or immunodiffusion techniques, and no studies have identified the specific tumor antigen with the immunoblotting method. In the present study, no significant immunoreactivity was noted between the IgG eluted from renal cortical tissues of the patient and renal cell carcinoma proteins. Further studies are necessary to establish the pathogenic mechanism of MGN associated with malignancy.

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          Cure of membranous nephropathy after resection of carcinoma.

          Clinical cure was effected in two patients with biopsy-proved membranous nephropathy associated with neoplasms. One had a complete histologic remission as well. The incidence of malignancy in an unselected group of patients with membranous nephropathy in our institution was 9%. Careful workup in all patients over age 40 years with membranous nephropathy should be done to exclude tumor.

            Author and article information

            S. Karger AG
            February 2002
            30 January 2002
            : 90
            : 2
            : 219-221
            aFirst Department of Medicine, Hamamatsu University School of Medicine and Divisions of bNephrology and cUrology, Seirei Hamamatsu General Hospital, Hamamatsu, Shizuoka, and dDepartment of Medicine, Teikyo University School of Medicine, Itabashi, Tokyo, Japan
            49047 Nephron 2002;90:219–221
            © 2002 S. Karger AG, Basel

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            Figures: 2, References: 15, Pages: 3
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