22
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Lifestyle factors and visceral adipose tissue: Results from the PREDIMED-PLUS study

      research-article

      Read this article at

      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Background

          Visceral adipose tissue (VAT) is a strong predictor of cardiometabolic health, and lifestyle factors may have a positive influence on VAT depot. This study aimed to assess the cross-sectional associations between baseline levels of physical activity (PA), sedentary behaviours (SB) and adherence to the Mediterranean diet (MedDiet) with VAT depot in older individuals with overweight/obesity and metabolic syndrome.

          Methods

          Baseline data of the PREDIMED-Plus study including a sample of 1,231 Caucasian men and women aged 55–75 years were used. Levels of leisure-time PA (total, light, and moderate-to-vigorous, in METs·min/day) and SB (total and TV-viewing, in h/day) were evaluated using validated questionnaires. Adherence to the MedDiet was evaluated using a 17-item energy-restricted MedDiet (erMedDiet) screener. The chair-stand test was used to estimate the muscle strength. VAT depot was assessed with DXA-CoreScan. Multivariable adjusted linear regression models were used to evaluate the association between lifestyle factors and VAT. For the statistics we had used multiadjusted linear regression models.

          Results

          Total leisure-time PA (100 METs·min/day: β -24.3g, -36.7;-11.9g), moderate-to-vigorous PA (β -27.8g, 95% CI -40.8;-14.8g), chair-stand test (repeat: β -11.5g, 95% CI -20.1;-2.93g) were inversely associated, and total SB (h/day: β 38.2g, 95% CI 14.7;61.7) positively associated with VAT. Light PA, TV-viewing time and adherence to an erMedDiet were not significantly associated with VAT.

          Conclusions

          In older adults with overweigh/obesity and metabolic syndrome, greater PA, muscle strength, and lower total SB were associated with less VAT depot. In this study, adherence to an erMedDiet was not associated with lower VAT.

          Related collections

          Most cited references28

          • Record: found
          • Abstract: found
          • Article: not found

          Sitting time and all-cause mortality risk in 222 497 Australian adults.

          Prolonged sitting is considered detrimental to health, but evidence regarding the independent relationship of total sitting time with all-cause mortality is limited. This study aimed to determine the independent relationship of sitting time with all-cause mortality. We linked prospective questionnaire data from 222 497 individuals 45 years or older from the 45 and Up Study to mortality data from the New South Wales Registry of Births, Deaths, and Marriages (Australia) from February 1, 2006, through December 31, 2010. Cox proportional hazards models examined all-cause mortality in relation to sitting time, adjusting for potential confounders that included sex, age, education, urban/rural residence, physical activity, body mass index, smoking status, self-rated health, and disability. During 621 695 person-years of follow-up (mean follow-up, 2.8 years), 5405 deaths were registered. All-cause mortality hazard ratios were 1.02 (95% CI, 0.95-1.09), 1.15 (1.06-1.25), and 1.40 (1.27-1.55) for 4 to less than 8, 8 to less than 11, and 11 or more h/d of sitting, respectively, compared with less than 4 h/d, adjusting for physical activity and other confounders. The population-attributable fraction for sitting was 6.9%. The association between sitting and all-cause mortality appeared consistent across the sexes, age groups, body mass index categories, and physical activity levels and across healthy participants compared with participants with preexisting cardiovascular disease or diabetes mellitus. Prolonged sitting is a risk factor for all-cause mortality, independent of physical activity. Public health programs should focus on reducing sitting time in addition to increasing physical activity levels.
            Bookmark
            • Record: found
            • Abstract: found
            • Article: found
            Is Open Access

            The Effect of Exercise on Visceral Adipose Tissue in Overweight Adults: A Systematic Review and Meta-Analysis

            Excessive visceral adipose tissue appears to trigger a cascade of metabolic disturbances that seem to coexist with ectopic fat storage in muscle, liver, heart and the ß-cell. Therefore, the reduction of visceral adipose tissue potentially plays a pivotal role in the treatment of the metabolic syndrome. The purpose of this systematic review and meta-analysis is to describe the overall effect of exercise on visceral adipose tissue and to provide an overview of the effect of different exercise regimes, without caloric restriction, on visceral adipose tissue in obese persons. A systematic literature search was performed according to the PRISMA statement for reporting systematic reviews and meta-analyses. The initial search resulted in 87 articles after removing duplicates. After screening on title, abstract and full-text 15 articles (totalling 852 subjects) fulfilled the a priori inclusion criteria. The quality of each eligible study was assessed in duplicate with “The Critical Review Form for Quantitative Studies”. Using random-effects weights, the standardized mean difference (Hedge's g) of the change in visceral adipose tissue was −0.497 with a 95% confidence interval of −0.655 to −0.340. The Z-value was −6.183 and the p-value (two tailed) was <0.001. A subgroup analysis was performed based on gender, type of training and intensity. Aerobic training of moderate or high intensity has the highest potential to reduce visceral adipose tissue in overweight males and females. These results suggest that an aerobic exercise program, without hypocaloric diet, can show beneficial effects to reduce visceral adipose tissue with more than 30 cm2 (on CT analysis) in women and more than 40 cm2 in men, even after 12 weeks.
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              A systematic review and meta-analysis of the effect of aerobic vs. resistance exercise training on visceral fat.

              It is increasingly recognized that the location of excess adiposity, particularly increased deposition of visceral adipose tissue (VAT), is important when determining the adverse health effects of overweight and obesity. Exercise therapy is an integral component of obesity management, but the most potent exercise prescription for VAT benefit is unclear. We aimed to evaluate the independent and synergistic effects of aerobic exercise (AEx) and progressive resistance training (PRT) and to directly compare the efficacy of AEx and PRT for beneficial VAT modulation. A systematic review and meta-analysis was performed to assess the efficacy of exercise interventions on VAT content/volume in overweight and obese adults. Relevant databases were searched to November 2010. Included studies were randomized controlled designs in which AEx or PRT in isolation or combination were employed for 4 weeks or more in adult humans, where computed tomography (CT) or magnetic resonance imaging (MRI) was used for quantification of VAT pre- and post-intervention. Of the 12196 studies from the initial search, 35 were included. After removal of outliers, there was a significant pooled effect size (ES) for the comparison between AEx therapy and control (-0.33, 95% CI: -0.52 to -0.14; P < 0.01) but not for the comparison between PRT therapy and control (0.09, 95% CI: -0.17 to -0.36; P = 0.49). Of the available nine studies which directly compared AEx with PRT, the pooled ES did not reach statistical significance (ES = 0.23, 95% CI: -0.02 to 0.50; P = 0.07 favouring AEx). The pooled ES did not reach statistical significance for interventions that combined AEx and PRT therapy vs. control (-0.28, 95% CI: -0.69 to 0.14; P = 0.19), for which only seven studies were available. These data suggest that aerobic exercise is central for exercise programmes aimed at reducing VAT, and that aerobic exercise below current recommendations for overweight/obesity management may be sufficient for beneficial VAT modification. Further investigation is needed regarding the efficacy and feasibility of multi-modal training as a means of reducing VAT. © 2011 The Authors. obesity reviews © 2011 International Association for the Study of Obesity.
                Bookmark

                Author and article information

                Contributors
                Role: ConceptualizationRole: Data curationRole: Formal analysisRole: Funding acquisitionRole: InvestigationRole: MethodologyRole: ResourcesRole: ValidationRole: VisualizationRole: Writing – original draftRole: Writing – review & editing
                Role: ConceptualizationRole: Data curationRole: Formal analysisRole: Funding acquisitionRole: InvestigationRole: MethodologyRole: ResourcesRole: SupervisionRole: ValidationRole: VisualizationRole: Writing – original draftRole: Writing – review & editing
                Role: Data curationRole: Funding acquisitionRole: InvestigationRole: ResourcesRole: VisualizationRole: Writing – review & editing
                Role: Data curationRole: Funding acquisitionRole: InvestigationRole: ResourcesRole: VisualizationRole: Writing – review & editing
                Role: Data curationRole: Funding acquisitionRole: InvestigationRole: ResourcesRole: VisualizationRole: Writing – review & editing
                Role: Data curationRole: Funding acquisitionRole: InvestigationRole: ResourcesRole: VisualizationRole: Writing – review & editing
                Role: Data curationRole: Funding acquisitionRole: InvestigationRole: ResourcesRole: VisualizationRole: Writing – review & editing
                Role: Data curationRole: Funding acquisitionRole: InvestigationRole: Project administrationRole: ResourcesRole: VisualizationRole: Writing – review & editing
                Role: Data curationRole: Funding acquisitionRole: InvestigationRole: ResourcesRole: VisualizationRole: Writing – review & editing
                Role: Data curationRole: Funding acquisitionRole: InvestigationRole: ResourcesRole: VisualizationRole: Writing – review & editing
                Role: Data curationRole: Funding acquisitionRole: InvestigationRole: ResourcesRole: VisualizationRole: Writing – review & editing
                Role: Data curationRole: Funding acquisitionRole: MethodologyRole: ValidationRole: VisualizationRole: Writing – review & editing
                Role: Data curationRole: MethodologyRole: ValidationRole: VisualizationRole: Writing – review & editing
                Role: Data curationRole: MethodologyRole: ValidationRole: VisualizationRole: Writing – review & editing
                Role: Data curationRole: Funding acquisitionRole: MethodologyRole: ValidationRole: VisualizationRole: Writing – review & editing
                Role: Data curationRole: Funding acquisitionRole: MethodologyRole: ValidationRole: VisualizationRole: Writing – review & editing
                Role: Data curationRole: Funding acquisitionRole: MethodologyRole: ValidationRole: VisualizationRole: Writing – review & editing
                Role: Data curationRole: Funding acquisitionRole: MethodologyRole: ValidationRole: VisualizationRole: Writing – review & editing
                Role: Data curationRole: Funding acquisitionRole: MethodologyRole: ValidationRole: VisualizationRole: Writing – review & editing
                Role: Data curationRole: Funding acquisitionRole: MethodologyRole: ValidationRole: VisualizationRole: Writing – review & editing
                Role: Editor
                Journal
                PLoS One
                PLoS ONE
                plos
                plosone
                PLoS ONE
                Public Library of Science (San Francisco, CA USA )
                1932-6203
                25 January 2019
                2019
                : 14
                : 1
                : e0210726
                Affiliations
                [1 ] Balearic Islands Health Research Institute (IdISBa), University Hospital Son Espases, Palma de Mallorca, Spain
                [2 ] CIBER Pathophysiology of Obesity and Nutrition (CIBEROBN), Health Institute Carlos III (ISCIII), Madrid, Spain
                [3 ] Department of Nutrition, Food Sciences and Physiology, Center for Nutrition Research, University of Navarra (UNAV), Pamplona, Spain
                [4 ] Human Nutrition Unit, University Hospital of Sant Joan de Reus, Department of Biochemistry and Biotechnology, Pere Virgili Institute for Health Research, Rovira i Virgili University, Reus, Spain
                [5 ] Department of Preventive Medicine and Public Health, University of Navarra, Pamplona, Spain
                [6 ] Department of Internal Medicine, IDIBAPS, Hospital Clinic, University of Barcelona, Barcelona, Spain
                [7 ] Department of Endocrinology, IDIBAPS, Hospital Clinic, University of Barcelona, Barcelona, Spain
                [8 ] CIBER Diabetes and Metabolic Diseases (CIBERdem), Health Institute Carlos III (ISCIII), Madrid, Spain
                [9 ] Institute for Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona, Spain
                [10 ] Primary Care, Health Service of Navarra-Osasunbidea, Pamplona, Spain
                [11 ] Division of Preventive Medicine, University of León, León, Spain
                [12 ] Lipids and Cardiovascular Epidemiology Research Unit, Municipal Institute of Medical Research (IMIM), Barcelona, Spain
                [13 ] Madrid Institute for Advanced Studies (IMDEA) Food Institute, Madrid, Spain
                University of Cordoba, SPAIN
                Author notes

                Competing Interests: The authors have declared that no competing interests exist.

                ¶ A complete list of the PREDIMED-Plus trial investigators is provided as Supporting Information ( S1 Text).

                Author information
                http://orcid.org/0000-0002-2947-1338
                http://orcid.org/0000-0001-5041-0778
                http://orcid.org/0000-0002-4389-1777
                http://orcid.org/0000-0003-2700-7459
                Article
                PONE-D-18-28856
                10.1371/journal.pone.0210726
                6347417
                30682078
                22825b6e-5f9f-44e1-91c0-2aa44de63db3
                © 2019 Galmes-Panades et al

                This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

                History
                : 4 October 2018
                : 28 December 2018
                Page count
                Figures: 0, Tables: 3, Pages: 15
                Funding
                Funded by: CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn) and Instituto de Salud Carlos III (ISCIII)
                Award ID: PI13/00462, PI13/01090, PI13/02184, PI14/00853, PI14/00728, PI14/01919, PI16/00501, PI16/00381, PI16/01522, PI17/00525, PI17/00532, PI17/00215, PI17/00926
                Funded by: funder-id http://dx.doi.org/10.13039/501100003741, Institució Catalana de Recerca i Estudis Avançats;
                Award ID: 340918
                Funded by: Recercaixa
                Award ID: 2013ACUP00194
                Funded by: SEMERGEN
                Award ID: SEMERGEN
                Funded by: International Nut & Dried Fruit Council – FESNAD (2014-2015)
                Award ID: 201302
                Funded by: funder-id http://dx.doi.org/10.13039/100004325, AstraZeneca;
                Award ID: T2D 2017
                Award Recipient :
                Funded by: Spanish Ministry of Economy, Industry and Competitiveness
                Award ID: FJCI-2015-24058
                Award Recipient :
                This work was supported by the official Spanish Institutions for funding scientific biomedical research, CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn) and Instituto de Salud Carlos III (ISCIII), through the Fondo de Investigación para la Salud (FIS), which is co-funded by the European Regional Development Fund (four coordinated FIS projects leaded by J.S.-S. and J.Vi., including the following projects: PI13/00462, PI13/01090, PI13/02184, PI14/00853, PI14/00728, PI14/01919, PI16/00501, PI16/00381, PI16/01522, PI17/00525, PI17/00532, PI17/00215, PI17/00926 and the Especial Action Project entitled: Implementación y evaluación de una intervención intensiva sobre la actividad física Cohorte PREDIMED-Plus [J.S.-S.]; the European Research Council (Advanced Research Grant 2013-2018; grant number 340918); the Recercaixa (grant number 2013ACUP00194) [J.S.-S.]; the SEMERGEN grant; International Nut & Dried Fruit Council – FESNAD (Long-term effects of an energy-restricted Mediterranean diet on mortality and cardiovascular disease 2014 –2015, No. 201302) [Miguel A. Martinez-Gonzalez]; the AstraZeneca Young Investigators Award in Category of Obesity and T2D 2017 [D.R.]; Juan de la Cierva-formación research grant (FJCI-2015-24058) of the Spanish Ministry of Economy, Industry and Competitiveness [J.K.]. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
                Categories
                Research Article
                Biology and Life Sciences
                Anatomy
                Biological Tissue
                Adipose Tissue
                Medicine and Health Sciences
                Anatomy
                Biological Tissue
                Adipose Tissue
                Biology and Life Sciences
                Biochemistry
                Lipids
                Fats
                Biology and Life Sciences
                Physiology
                Physiological Parameters
                Body Weight
                Obesity
                Medicine and Health Sciences
                Physiology
                Physiological Parameters
                Body Weight
                Obesity
                Research and Analysis Methods
                Mathematical and Statistical Techniques
                Statistical Methods
                Regression Analysis
                Linear Regression Analysis
                Physical Sciences
                Mathematics
                Statistics
                Statistical Methods
                Regression Analysis
                Linear Regression Analysis
                Biology and Life Sciences
                Nutrition
                Diet
                Medicine and Health Sciences
                Nutrition
                Diet
                Medicine and Health Sciences
                Endocrinology
                Endocrine Disorders
                Diabetes Mellitus
                Medicine and Health Sciences
                Metabolic Disorders
                Diabetes Mellitus
                Medicine and Health Sciences
                Public and Occupational Health
                Physical Activity
                Research and Analysis Methods
                Bioassays and Physiological Analysis
                Muscle Analysis
                Custom metadata
                There are restrictions on the availability of data for the PREDIMED-Plus study, due to the signed consent agreements around data sharing, which only allow access to external researchers for research following the project purposes. Requestors wishing to access the PREDIMED-Plus trial data used in this study can request it to the PREDIMED-Plus trial Steering Committee: predimed_plus_scommittee@ 123456googlegroups.com .

                Uncategorized
                Uncategorized

                Comments

                Comment on this article