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Evidence that increased ovarian aromatase activity and expression account for higher estradiol levels in African American compared with Caucasian women.

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      Abstract

      Serum estradiol levels are significantly higher across the menstrual cycle in African American (AAW) compared with Caucasian women (CW) in the presence of similar FSH levels, yet the mechanism underlying this disparity is unknown.

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      Affiliations
      [1 ] Reproductive Endocrine Unit (N.D.S., S.S.S., C.K.W., K.H.C., J.M.A., P.M.S., J.E.H.), Department of Medicine, Massachusetts General Hospital, Boston Massachusetts 02114; and Division of Endocrinology (N.D.S.), Children's Hospital Boston, and Center for Infertility and Reproductive Surgery (S.S.S., J.H.F.), Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Boston, Massachusetts 02115.
      Journal
      J. Clin. Endocrinol. Metab.
      The Journal of clinical endocrinology and metabolism
      1945-7197
      0021-972X
      Apr 2014
      : 99
      : 4
      24285681 jc.2013-2398 10.1210/jc.2013-2398 3973772

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