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      Berberine-loaded polylactic acid nanofiber scaffold as a drug delivery system: The relationship between chemical characteristics, drug-release behavior, and antibacterial efficiency

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          Abstract

          Hydrophobic berberine powder (BBR) and hydrophilic BBR nanoparticles (BBR NPs) were loaded into an electrospun polylactic acid (PLA) nanofiber scaffold for modulating the release behavior of BBR in an aqueous medium. The BBR release from the BBR/PLA and BBR NPs/PLA nanofiber scaffolds was investigated in relation to their chemical characteristics, BBR dispersion into nanofibers, and wettability. The BBR release profiles strongly influenced the antibacterial efficiency of the scaffolds over time. When the BBR was loaded, the BBR/PLA nanofiber scaffold exhibited an extremely hydrophobic feature, causing a triphasic release profile in which only 9.8 wt % of the loaded BBR was released in the first 24 h. This resulted in a negligible inhibitory effect against methicillin-resistant Staphylococcus aureus bacteria. Meanwhile, the BBR NPs/PLA nanofiber scaffold had more wettability and higher concentration of BBR NPs dispersed on the surface of PLA nanofibers. This led to a sustained release of 75 wt % of the loaded BBR during the first 24 h, and consequently boosted the antibacterial effectiveness. Moreover, the cytotoxicity test revealed that the BBR NPs/PLA nanofiber scaffold did not induce any changes in morphology and proliferation of MA-104 cell monolayers. It suggests that the BBR/PLA and BBR NPs/PLA nanofiber scaffolds can be used in different biomedical applications, such as wound dressing, drug delivery systems, and tissue engineering, according to the requirement of BBR concentration for the desired therapeutic effects.

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          Electrospun Nanofibers for Drug Delivery

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            Author and article information

            Contributors
            Role: Guest Editor
            Journal
            Beilstein J Nanotechnol
            Beilstein J Nanotechnol
            Beilstein Journal of Nanotechnology
            Beilstein-Institut (Trakehner Str. 7-9, 60487 Frankfurt am Main, Germany )
            2190-4286
            2024
            12 January 2024
            : 15
            : 71-82
            Affiliations
            [1 ] Phenikaa University Nano Institute (PHENA), Phenikaa University, Hanoi 12116, Vietnam ( https://ror.org/03anxx281)
            [2 ] School of Material Science and Technology, Hanoi University of Science and Technology, Hanoi 11600, Vietnam ( https://ror.org/04nyv3z04)
            [3 ] Faculty of Biomedical Sciences, Phenikaa University, Hanoi 12116, Vietnam ( https://ror.org/03anxx281)
            Author notes
            [§]

            Phone No. +84924926886

            Author information
            https://orcid.org/0000-0002-5197-5612
            https://orcid.org/0000-0001-7239-8458
            Article
            10.3762/bjnano.15.7
            10790648
            38229677
            2285d0a1-ee52-45cd-ab63-68ee7d027431
            Copyright © 2024, Le et al.

            This is an open access article licensed under the terms of the Beilstein-Institut Open Access License Agreement ( https://www.beilstein-journals.org/bjnano/terms/terms), which is identical to the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0). The reuse of material under this license requires that the author(s), source and license are credited. Third-party material in this article could be subject to other licenses (typically indicated in the credit line), and in this case, users are required to obtain permission from the license holder to reuse the material.

            History
            : 28 September 2023
            : 19 December 2023
            Funding
            Funded by: The Development Program of Basic Science in the Fields of Chemistry, Life Sciences, Earth Sciences, and Marine Sciences, Vietnam Ministry of Science and Technology;
            Award ID: ĐTĐL.CN-111/21
            This work was supported by The Development Program of Basic Science in the Fields of Chemistry, Life Sciences, Earth Sciences, and Marine Sciences, Vietnam Ministry of Science and Technology, under Grant ĐTĐL.CN-111/21.
            Categories
            Full Research Paper
            Nanoscience
            Nanotechnology

            antibacterial activity,berberine,drug-release system,electrospun nanofiber,polylactic acid

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