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      Multigene Panel Testing Detects Equal Rates of Pathogenic BRCA1/2 Mutations and has a Higher Diagnostic Yield Compared to Limited BRCA1/2 Analysis Alone in Patients at Risk for Hereditary Breast Cancer.

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          Abstract

          Recently introduced multigene panel testing including BRCA1 and BRCA2 genes for hereditary cancer risk has raised concerns with the ability to detect all deleterious BRCA1/2 mutations compared to older methods of sequentially testing BRCA1/2 separately. The purpose of this study was to evaluate rates of pathogenic BRCA1/2 mutations and variants of uncertain significance (VUS) between previous restricted algorithms of genetic testing and newer approaches of multigene testing.

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          Author and article information

          Journal
          Ann. Surg. Oncol.
          Annals of surgical oncology
          Springer Nature
          1534-4681
          1068-9265
          Oct 2015
          : 22
          : 10
          Affiliations
          [1 ] Department of Surgical Oncology, Breastlink, Orange, CA, USA, nimsikapoor@gmail.com.
          Article
          10.1245/s10434-015-4754-2
          26219241
          2287738a-9201-42c7-80e1-15beec193d54
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