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      Lens Permeability Changes in Relation to X-Ray Induced Cataract as Detected by Cell-Mediated Immune Activity


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          The experimental radiation cataract in rabbits served as a research model in an investigation of the relation between cataract progression and lens permeability changes. Slit-lamp examination revealed the first lens opacities 12 weeks following X-irradiation. Sensitization of the cellular immune system of the rabbits as detected by skin tests and lymphocyte stimulation was found to be maximal 8 weeks following X-ray treatment. This sensitization was predominantly directed to low molecular weight lens proteins, i.e., proteins other than intact α-crystallin. The results point to a leakage of low molecular weight lens proteins out of the lens before cataract is clinically detectable.

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          Author and article information

          Ophthalmic Res
          Ophthalmic Research
          S. Karger AG
          03 December 2009
          : 12
          : 4
          : 230-234
          Institute of Ophthalmology, University of Nijmegen, Nijmegen
          265082 Ophthalmic Res 1980;12:230–234
          © 1980 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          : 20 August 1979
          : 21 December 1979
          Page count
          Pages: 5
          Original Paper

          Vision sciences,Ophthalmology & Optometry,Pathology
          Lens-radiation cataract,Permeability,Lens crystallins,Skin test,Lymphocyte stimulation


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