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    [A new form of cell death: Parthanatos].

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    Journal: Yi chuan = Hereditas / Zhongguo yi chuan xue hui bian ji

    Keywords: Cell Death, drug effects, physiology, Diabetes Complications, pathology, Humans, Parkinson Disease, Poly(ADP-ribose) Polymerases, metabolism, Reperfusion Injury, Signal Transduction, immunology, Stroke

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        Abstract

        Parthanatos is a form of cell death, which often occurs in many diseases such as stroke, Parkinson's disease, heart attack, diabetes, and ischemia reperfusion injury. In a cell, the activation of PARP-1 caused by excitotoxicity leads to Parthanatos, which is also known as PARP-1-dependent cell death. There are multiple cell signaling pathways involved in the process of Parthanatos, which have not been fully understood. The main focus of this article is underlying molecular mechanisms of Parthanatos.

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        PubMed ID:: 20870608

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        ScienceOpen disciplines: Chemistry

        Keywords: Cell Death, drug effects, physiology, Diabetes Complications, pathology, Humans, Parkinson Disease, Poly(ADP-ribose) Polymerases, metabolism, Reperfusion Injury, Signal Transduction, immunology, Stroke

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