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A muscarinic receptor agonist mobilizes Ca2+ from caffeine and inositol-1,4,5-trisphosphate-sensitive Ca2+ stores in cat adrenal chromaffin cells
January 1992
January 1992
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Abstract
To gain some understanding of the characteristics of intracellular Ca2+ stores of
cat adrenal chromaffin cells, we investigated the effects of ryanodine, a blocker
of Ca(2+)-induced Ca2+ release channels in muscle, on both cytosolic Ca2+ concentration
and catecholamine secretion induced by caffeine or methacholine. The results suggest
that Ca2+ stores consist of at least two compartments, one which is sensitive to both
caffeine and inositol-1,4,5-trisphosphate (IP3), and the other which is sensitive
to IP3 alone.