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      Acute Renal Failure in Idiopathic Nephrotic Syndrome

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          Abstract

          In 4 adults with idiopathic nephrotic syndrome an acute renal failure with prolonged anuria has been observed. At renal histology 1 patient showed minimal glomerular changes and 3 showed focal glomerulosclerosis. No vascular abnormalities were seen. In all cases severe tubular lesions with casts and cell debris in the lumina were observed. In 2 patients renal function improved after 3 and 6 months, respectively; the remaining 2 died after several months from the onset of acute renal failure being still anuric. Although the pathogenesis of this complication is unknown, tubular obstruction by proteinaceous casts and vasoconstriction may play an important role. The prognosis of this complication is severe, but the possibility of spontaneous recovery even after protracted anuria cannot be ruled out.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1981
          1981
          02 December 2008
          : 28
          : 4
          : 186-191
          Affiliations
          aDivisione di Nefrologia e Dialisi, Ospedale Policlinico, Milano, Italia; bIstituto di Urologia, Università di Cagliari, Italia; cInstitut für Pathologie, Universität Basel, Schweiz
          Article
          182173 Nephron 1981;28:186–191
          10.1159/000182173
          7301004
          © 1981 S. Karger AG, Basel

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          Pages: 6
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          Original Paper

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