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The effect of O-1602, an atypical cannabinoid, on morphine-induced conditioned place preference and physical dependence.

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      Abstract

      Previous studies show that some non-CB1/non-CB2 effects of cannabinoids are mediated through G protein coupled receptor 55 (GPR55). As this receptor is activated by some of cannabinoid receptor ligands and is involved in the modulation of pain, it was hypothesized that this receptor may also interact with opioids. This study examined the effect of atypical cannabinoid O-1602 as a GPR55 agonist on morphine-induced conditioned place preference (CPP) and physical dependence.

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      Affiliations
      [1 ] Neurocognitive Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
      [2 ] Pharmaceutical Research Center, Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
      [3 ] Physiology-Pharmacology Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
      [4 ] Pharmaceutical Research Center, Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address: roohbakhsha@mums.ac.ir.
      Journal
      Pharmacol Rep
      Pharmacological reports : PR
      1734-1140
      1734-1140
      Jun 2016
      : 68
      : 3
      26971034 S1734-1140(16)00003-7 10.1016/j.pharep.2015.12.009
      Copyright © 2016 Institute of Pharmacology, Polish Academy of Sciences. Published by Elsevier Urban & Partner Sp. z o.o. All rights reserved.

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