Elizabeth P. Harausz:
ORCID: http://orcid.org/0000-0001-8117-0607
Role: ConceptualizationRole: Data curationRole: Formal analysisRole: Writing – original
draft
Anthony J. Garcia-Prats: Role: ConceptualizationRole: Data curationRole: MethodologyRole: SupervisionRole:
Writing – review & editing
Stephanie Law: Role: Formal analysisRole: Writing – review & editing
H. Simon Schaaf: Role: ConceptualizationRole: Data curationRole: Formal analysisRole: InvestigationRole:
MethodologyRole: SupervisionRole: Writing – review & editing
Tamara Kredo: Role: Formal analysisRole: MethodologyRole: Writing – review & editing
James A. Seddon:
ORCID: http://orcid.org/0000-0002-2296-2302
Role: ConceptualizationRole: Data curationRole: InvestigationRole: MethodologyRole:
Writing – review & editing
Dick Menzies: Role: ConceptualizationRole: Data curationRole: Formal analysisRole: InvestigationRole:
MethodologyRole: Writing – review & editing
Anna Turkova: Role: Formal analysisRole: MethodologyRole: Writing – review & editing
Jay Achar: Role: Data curationRole: InvestigationRole: Writing – review & editing
Farhana Amanullah: Role: Data curationRole: InvestigationRole: Writing – review & editing
Pennan Barry: Role: Data curationRole: InvestigationRole: Writing – review & editing
Mercedes Becerra: Role: Data curationRole: InvestigationRole: Writing – review & editing
Edward D. Chan: Role: Data curationRole: InvestigationRole: Writing – review & editing
Pei Chun Chan:
ORCID: http://orcid.org/0000-0001-7424-1868
Role: Data curationRole: InvestigationRole: Writing – review & editing
Domnica Ioana Chiotan: Role: Data curationRole: InvestigationRole: Writing – review & editing
Aldo Crossa:
ORCID: http://orcid.org/0000-0003-3903-3320
Role: Data curationRole: InvestigationRole: Writing – review & editing
Peter C. Drobac:
ORCID: http://orcid.org/0000-0001-5190-6767
Role: Data curationRole: InvestigationRole: Writing – review & editing
Lee Fairlie: Role: Data curationRole: InvestigationRole: Writing – review & editing
Dennis Falzon:
ORCID: http://orcid.org/0000-0001-8798-7909
Role: ConceptualizationRole: ResourcesRole: Writing – review & editing
Jennifer Flood: Role: Data curationRole: InvestigationRole: Writing – review & editing
Medea Gegia: Role: Data curationRole: InvestigationRole: Writing – review & editing
Robert M. Hicks:
ORCID: http://orcid.org/0000-0001-8861-1225
Role: Data curationRole: InvestigationRole: Writing – review & editing
Petros Isaakidis:
ORCID: http://orcid.org/0000-0002-7881-1554
Role: Data curationRole: InvestigationRole: Writing – review & editing
SM Kadri:
ORCID: http://orcid.org/0000-0002-7855-1043
Role: Data curationRole: InvestigationRole: Writing – review & editing
Beate Kampmann: Role: Data curationRole: InvestigationRole: Writing – review & editing
Shabir A. Madhi: Role: Data curationRole: Writing – review & editing
Else Marais: Role: Data curationRole: InvestigationRole: Writing – review & editing
Andrei Mariandyshev:
ORCID: http://orcid.org/0000-0002-8485-5625
Role: Data curationRole: InvestigationRole: Writing – review & editing
Ana Méndez-Echevarría: Role: Data curationRole: InvestigationRole: Writing – review & editing
Brittany Kathryn Moore: Role: Data curationRole: InvestigationRole: Writing – review & editing
Parpieva Nargiza: Role: Data curationRole: InvestigationRole: Writing – review & editing
Iveta Ozere: Role: Data curationRole: InvestigationRole: Writing – review & editing
Nesri Padayatchi:
ORCID: http://orcid.org/0000-0003-2543-9071
Role: Data curationRole: InvestigationRole: Writing – review & editing
Saleem- ur-Rehman: Role: Data curationRole: InvestigationRole: Writing – review & editing
Natasha Rybak: Role: Data curationRole: InvestigationRole: Writing – review & editing
Begoña Santiago-Garcia: Role: Data curationRole: InvestigationRole: Writing – review & editing
N. Sarita Shah: Role: Data curationRole: InvestigationRole: Writing – review & editing
Sangeeta Sharma: Role: Data curationRole: InvestigationRole: Writing – review & editing
Tae Sun Shim: Role: Data curationRole: InvestigationRole: Writing – review & editing
Alena Skrahina: Role: Data curationRole: InvestigationRole: Writing – review & editing
Antoni Soriano-Arandes:
ORCID: http://orcid.org/0000-0001-9613-7228
Role: Data curationRole: InvestigationRole: Writing – review & editing
Martin van den Boom:
ORCID: http://orcid.org/0000-0002-6417-6668
Role: Data curationRole: ResourcesRole: Writing – review & editing
Marieke J. van der Werf:
ORCID: http://orcid.org/0000-0001-8021-1358
Role: Data curationRole: InvestigationRole: Writing – review & editing
Tjip S. van der Werf: Role: Data curationRole: InvestigationRole: Writing – review & editing
Bhanu Williams: Role: Data curationRole: InvestigationRole: Writing – review & editing
Elena Yablokova: Role: Data curationRole: InvestigationRole: Writing – review & editing
Jae-Joon Yim: Role: Data curationRole: InvestigationRole: Writing – review & editing
Jennifer Furin:
ORCID: http://orcid.org/0000-0002-0825-7199
Role: ConceptualizationRole: Data curationRole: InvestigationRole: MethodologyRole:
Writing – review & editing
Anneke C. Hesseling: Role: ConceptualizationRole: Data curationRole: Funding acquisitionRole: MethodologyRole:
Project administrationRole: ResourcesRole: SupervisionRole: Writing – review & editing
John Z. Metcalfe: Role: Academic Editor
Journal ID (nlm-ta): PLoS Med
Journal ID (iso-abbrev): PLoS Med
Journal ID (publisher-id): plos
Journal ID (pmc): plosmed
Title:
PLoS Medicine
Publisher:
Public Library of Science
(San Francisco, CA USA
)
ISSN
(Print):
1549-1277
ISSN
(Electronic):
1549-1676
Publication date
(Electronic):
11
July
2018
Publication date Collection:
July
2018
Volume: 15
Issue: 7
Electronic Location Identifier: e1002591
Affiliations
[1
]
Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Medicine
and Health Sciences, Stellenbosch University, Tygerberg, South Africa
[2
]
Military HIV Research Program, Bethesda, Maryland, United States of America
[3
]
Montreal Chest Institute, McGill University, Montreal, Quebec, Canada
[4
]
Cochrane South Africa, South African Medical Research Council, Cape Town, South Africa
[5
]
Centre for International Child Health, Imperial College, London, United Kingdom
[6
]
Imperial College Healthcare NHS Trust, Institute of Clinical Trials and Methodology,
London, United Kingdom
[7
]
Manson Unit, Médecins Sans Frontières (MSF), London, United Kingdom
[8
]
The Indus Hospital, Karachi, Pakistan
[9
]
California Department of Public Health, Sacramento, California, United States of America
[10
]
Partners In Health, Harvard Medical School, and Brigham and Women's Hospital, Boston,
Massachusetts, United States of America
[11
]
Denver Veterans Affairs Medical Center, National Jewish Health, Denver, Colorado,
United States of America
[12
]
Division of Chronic Infectious Disease, Centers for Disease Control, Taipei, Taiwan
[13
]
Epidemiological Surveillance Department, Romanian National TB Program, Bucharest,
Romania
[14
]
New York City Department of Health and Mental Hygiene, New York, New York, United
States of America
[15
]
Wits Reproductive Health & HIV Institute (WRHI), University of the Witwatersrand,
Johannesburg, South Africa
[16
]
Laboratories, Diagnostics and Drug Resistance Unit, Global TB Programme, World Health
Organization, Geneva, Switzerland
[17
]
Technical Support Coordination, Global TB Programme, World Health Organization, Geneva,
Switzerland
[18
]
Albert Einstein College of Medicine, Bronx, New York, United States of America
[19
]
Médecins Sans Frontières (MSF)/Doctors Without Borders, Mumbai, India
[20
]
Disease Control, Directorate of Health Services, Kashmir, India
[21
]
Paediatric Infection & Immunity, Centre of International Child Health, Imperial College
London, London, United Kingdom
[22
]
Vaccines & Immunity Theme, MRC Unit The Gambia, Banjul, The Gambia
[23
]
Medical Research Council: Respiratory and Meningeal Pathogens Research Unit, and Department
of Science and Technology/National Research Foundation: Vaccine Preventable Diseases,
University of the Witwatersrand, Johannesburg, South Africa
[24
]
Department of Clinical Microbiology and Infectious Diseases, University of the Witwatersrand
and the National Health Laboratory Services, Johannesburg, South Africa
[25
]
Northern State Medical University, Arkhangelsk, Russian Federation
[26
]
Pediatric, Infectious and Tropical Diseases Department, Hospital La Paz, Madrid, Spain
[27
]
Division of Global HIV and TB, U.S. Centers for Disease Control and Prevention, Atlanta,
Georgia, United States of America
[28
]
Republican Scientific Medical Center of Phtiziology and Pulmonology, Ministry of Health,
Tashkent, Uzbekistan
[29
]
Riga Eastern Clinical University Hospital, Centre for Tuberculosis and Lung Diseases,
Riga, Latvia
[30
]
CAPRISA, MRC TB-HIV Pathogenesis Unit, Durban, South Africa
[31
]
Director Health Services, Kashmir, India
[32
]
Alpert Medical School of Brown University, Providence, Rhode Island, United States
of America
[33
]
Pediatric Infectious Diseases Unit, Instituto de Investigación Sanitaria Gregorio
Marañón, Hospital General Universitario Gregorio Marañón, Madrid, Spain
[34
]
Department of Pediatrics, National Institute of Tuberculosis and Respiratory Diseases,
New Delhi, India
[35
]
Department of Pulmonary and Critical Care Medicine, University of Ulsan College of
Medicine, Asan Medical Center, Seoul, South Korea
[36
]
The Republican Research and Practical Centre for Pulmonology and TB, Minsk, Belarus
[37
]
Pediatric Infectious Diseases and Immunodeficiencies Unit, Unit of International Health-Tuberculosis
Drassanes-Vall Hebron, Hospital Universitari Vall d'Hebron, Barcelona, Spain
[38
]
Joint Tuberculosis, HIV & Viral Hepatitis Programme, WHO Regional Office for Europe,
Copenhagen, Denmark
[39
]
Disease Programme Tuberculosis, European Centre for Disease Prevention and Control,
Stockholm, Sweden
[40
]
University Medical Center Groningen, Groningen, the Netherlands
[41
]
Northwick Park Hospital, London Northwest Healthcare NHS Trust, London, United Kingdom
[42
]
Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine,
Seoul National University College of Medicine, Seoul, South Korea
[43
]
Department of Global Health and Social Medicine, Harvard Medical School, Boston, Massachusetts,
United States of America
University of California, San Francisco, UNITED STATES
Author notes
I have read the journal's policy and the authors of this manuscript have the following
competing interests: DF, MG, and MvDB are staff members of the World Health Organization
(WHO). AJGP's institution, Stellenbosch University, has received funds from the US
National Institutes of Health for an observational study of the pharmacokinetics and
safety of key second-line TB medications in children, for which AJGP is the Principal
Investigator. AJGP's institution has also received funds from Otsuka Pharmaceuticals
for implementation of pediatric trial of the novel TB drug delamanid; AJGP is the
PI for his site for this trial.
[¤a]
Current address: Department of Radiology and Biomedical Imaging, University of California,
San Francisco, San Francisco, California, United States of America
[¤b]
Current address: Division of Global HIV and TB, U.S. Centers for Disease Control and
Prevention, Atlanta, Georgia, United States of America
¶ Membership of the Collaborative Group for Meta-Analysis of Paediatric Individual
Patient Data in MDR-TB is provided in the Acknowledgments.
Author information
Article
Publisher ID:
PMEDICINE-D-17-00947
DOI: 10.1371/journal.pmed.1002591
PMC ID: 6040687
PubMed ID: 29995958
SO-VID: 22d79b3a-90ff-4a42-be08-26abb971abf8
License:
This is an open access article, free of all copyright, and may be freely reproduced,
distributed, transmitted, modified, built upon, or otherwise used by anyone for any
lawful purpose. The work is made available under the
Creative Commons CC0 public domain dedication.
Funded by: funder-id http://dx.doi.org/10.13039/100004423, World Health Organization;
Award Recipient
:
ORCID: http://orcid.org/0000-0001-8117-0607
Elizabeth P. Harausz
Funding for this study was provided through a USAID grant made available by the World
Health Organization. DF, MG, and MvdB are WHO employees but not involved in decisions
to allocate funding. The funder had no role in study design, data collection and analysis,
decision to publish, or preparation of the manuscript.
Subject:
Research Article
Subject:
Medicine and Health Sciences
Subject:
Infectious Diseases
Subject:
Bacterial Diseases
Subject:
Tuberculosis
Subject:
Multi-Drug-Resistant Tuberculosis
Subject:
Medicine and Health Sciences
Subject:
Tropical Diseases
Subject:
Tuberculosis
Subject:
Multi-Drug-Resistant Tuberculosis
Subject:
Medicine and health sciences
Subject:
Infectious diseases
Subject:
Viral diseases
Subject:
HIV infections
Subject:
Medicine and Health Sciences
Subject:
Infectious Diseases
Subject:
Bacterial Diseases
Subject:
Tuberculosis
Subject:
Medicine and Health Sciences
Subject:
Tropical Diseases
Subject:
Tuberculosis
Subject:
Medicine and Health Sciences
Subject:
Pharmaceutics
Subject:
Drug Therapy
Subject:
Biology and Life Sciences
Subject:
Immunology
Subject:
Vaccination and Immunization
Subject:
Antiviral Therapy
Subject:
Antiretroviral Therapy
Subject:
Medicine and Health Sciences
Subject:
Immunology
Subject:
Vaccination and Immunization
Subject:
Antiviral Therapy
Subject:
Antiretroviral Therapy
Subject:
Medicine and Health Sciences
Subject:
Public and Occupational Health
Subject:
Preventive Medicine
Subject:
Vaccination and Immunization
Subject:
Antiviral Therapy
Subject:
Antiretroviral Therapy
Subject:
Medicine and health sciences
Subject:
Diagnostic medicine
Subject:
HIV diagnosis and management
Subject:
People and Places
Subject:
Population Groupings
Subject:
Age Groups
Subject:
Children
Subject:
People and Places
Subject:
Population Groupings
Subject:
Families
Subject:
Children
Subject:
Medicine and Health Sciences
Subject:
Diagnostic Medicine
Subject:
Tuberculosis Diagnosis and Management
