Blog
About

11
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Brain modularity controls the critical behavior of spontaneous activity

      1 , 2 , 3 , a , 4

      Scientific Reports

      Nature Publishing Group

      Read this article at

      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          The human brain exhibits a complex structure made of scale-free highly connected modules loosely interconnected by weaker links to form a small-world network. These features appear in healthy patients whereas neurological diseases often modify this structure. An important open question concerns the role of brain modularity in sustaining the critical behaviour of spontaneous activity. Here we analyse the neuronal activity of a model, successful in reproducing on non-modular networks the scaling behaviour observed in experimental data, on a modular network implementing the main statistical features measured in human brain. We show that on a modular network, regardless the strength of the synaptic connections or the modular size and number, activity is never fully scale-free. Neuronal avalanches can invade different modules which results in an activity depression, hindering further avalanche propagation. Critical behaviour is solely recovered if inter-module connections are added, modifying the modular into a more random structure.

          Related collections

          Author and article information

          Journal
          Sci Rep
          Sci Rep
          Scientific Reports
          Nature Publishing Group
          2045-2322
          13 March 2014
          2014
          : 4
          Affiliations
          [1 ]Physics Department, University of Naples Federico II , Napoli, Italy
          [2 ]Institute Computational Physics for Engineering Materials , ETH, Zürich, CH
          [3 ]Departamento de Física, Universidade Federal do Ceará , 60451-970 Fortaleza, Ceará, Brazil
          [4 ]Department of Industrial and Information Engineering, Second University of Naples and INFN Gr. Coll. Salerno , Aversa (CE), Italy
          Author notes
          Article
          srep04312
          10.1038/srep04312
          3952147
          24621482
          Copyright © 2014, Macmillan Publishers Limited. All rights reserved

          This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/

          Categories
          Article

          Uncategorized

          Comments

          Comment on this article