10
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Long-term proton pump inhibitor (PPI) use and the development of gastric pre-malignant lesions.

      1 , ,
      The Cochrane database of systematic reviews
      Wiley-Blackwell

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Proton pump inhibitors (PPIs) are the most effective drugs to reduce gastric acid secretion. PPIs are one of the most commonly prescribed classes of medications worldwide. Apart from short-term application, maintenance therapy with PPIs is recommended and increasingly used in certain diseases, such as Zollinger-Ellison syndrome and gastro-oesophageal reflux disease, especially for people with erosive oesophagitis or Barrett's oesophagus. Although PPIs are generally safe, their efficacy and safety of long-term use remains unclear. The question of whether the long-term use of PPIs could promote the development of gastric pre-malignant lesions has been widely investigated, but results are inconsistent. Limited insight on this problem leads to a dilemma in decision making for long-term PPI prescription.

          Related collections

          Author and article information

          Journal
          Cochrane Database Syst Rev
          The Cochrane database of systematic reviews
          Wiley-Blackwell
          1469-493X
          1361-6137
          Dec 02 2014
          : 12
          Affiliations
          [1 ] Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Box 281, Stockholm, SE- 17177, Sweden. huan.song@ki.se.
          Article
          10.1002/14651858.CD010623.pub2
          25464111
          230731de-91b3-4656-b751-a9591f14fcc5
          History

          Comments

          Comment on this article