+1 Recommend
1 collections
      • Record: found
      • Abstract: found
      • Article: found

      Bidirectional Thyroxine Exchange in Pregnant Sheep

      Read this article at

          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.


          Radioisotopic exchange studies in pregnant sheep support the concept of a small but significant bidirectional transplacental thyroxine flux between mother and fetus in the last bimester. The direction and extent of this transfer is not known. There appears to be a rapid and appreciable deiodination of the administered radioactive thyroxine, but no indication that this iodide appeared to any measurable amount as radiothyroxine. The relatively small quantities of radioactive thyroxine transferred become quite significant when compared to the extremely small concentrations of free thyroxine presented to each placental interface.

          Related collections

          Author and article information

          Horm Res Paediatr
          Hormone Research in Paediatrics
          S. Karger AG
          21 November 2008
          : 3
          : 4
          : 235-249
          Department of Medicine of the Harvard Medical School and Peter Bent Brigham Hospital, and Department of Surgery of the Boston University School of Medicine and UniversityHospital, Boston, Mass
          178274 Hormones 1972;3:235–249
          © 1972 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 15


          Comment on this article