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      Precision medicine: Beyond the inflection point.

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          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          A confluence of biological, physical, engineering, computer, and health sciences is setting the stage for a transformative leap toward data-driven, mechanism-based health and health care for each individual.

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          The cancer cell map initiative: defining the hallmark networks of cancer.

          Nevan Krogan, Scott L. Lippman, David Agard … (2015)
          Progress in DNA sequencing has revealed the startling complexity of cancer genomes, which typically carry thousands of somatic mutations. However, it remains unclear which are the key driver mutations or dependencies in a given cancer and how these influence pathogenesis and response to therapy. Although tumors of similar types and clinical outcomes can have patterns of mutations that are strikingly different, it is becoming apparent that these mutations recurrently hijack the same hallmark molecular pathways and networks. For this reason, it is likely that successful interpretation of cancer genomes will require comprehensive knowledge of the molecular networks under selective pressure in oncogenesis. Here we announce the creation of a new effort, The Cancer Cell Map Initiative (CCMI), aimed at systematically detailing these complex interactions among cancer genes and how they differ between diseased and healthy states. We discuss recent progress that enables creation of these cancer cell maps across a range of tumor types and how they can be used to target networks disrupted in individual patients, significantly accelerating the development of precision medicine.
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            Toward precision medicine: a new social contract?

            Susan Desmond-Hellmann (2012)
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              Assessing the Significance of BRCA1 and BRCA2 Mutations in Pancreatic Cancer.

              Julia Carnevale, Alan Ashworth (2015)
              Article 0 comments Cited 12 times – based on 0 reviews     Review now
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                Author and article information

                Journal
                Journal ID (iso-abbrev): Sci Transl Med
                Title: Science translational medicine
                ISSN (Electronic): 1946-6242
                ISSN (Print): 1946-6234
                Publication date (Electronic): Aug 12 2015
                Volume: 7
                Issue: 300
                Affiliations
                [1 ] School of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.
                [2 ] School of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA. Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA. yamamoto@ucsf.edu.
                Article
                Publisher Item ID: 7/300/300ps17
                DOI: 10.1126/scitranslmed.aaa9970
                PubMed ID: 26268311
                SO-VID: 230ffea4-082e-4bd9-933f-93eef983d19a
                Copyright statement: Copyright © 2015, American Association for the Advancement of Science.
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