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      Tumor delivery of macromolecular drugs based on the EPR effect.

      Advanced Drug Delivery Reviews

      Animals, Capillary Permeability, Drug Delivery Systems, Extravasation of Diagnostic and Therapeutic Materials, metabolism, physiopathology, Gene Transfer Techniques, Humans, Macromolecular Substances, Neoplasms, blood supply, drug therapy

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          Abstract

          Enhanced permeability and retention (EPR) effect is the physiology-based principal mechanism of tumor accumulation of large molecules and small particles. This specific issue of Advanced Drug Delivery Reviews is summing up multiple data on the EPR effect-based drug design and clinical outcome. In this commentary, the role of the EPR effect in the intratumoral delivery of protein and peptide drugs, macromolecular drugs and drug-loaded long-circulating pharmaceutical nanocarriers is briefly discussed together with some additional opportunities for drug delivery arising from the initial EPR effect-mediated accumulation of drug-containing macromolecular systems in tumors. Copyright © 2010 Elsevier B.V. All rights reserved.

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          20304019
          10.1016/j.addr.2010.03.011

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