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      Maturation of Fiber Membranes in the Human Eye Lens

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          Abstract

          Electron microscopic, freeze fracture and cholesterol cytochemical studies have revealed that the maturation of lens fibers is accompanied by considerable changes in the ultrastructure of their limiting membranes. These changes are in line with biochemical studies on the cholesterol content in the lens and support the physiological notion that upon maturation lens membranes are transformed from normal permeable to nonleaky membranes. In addition it is shown that early cortical changes involve disturbances of lens membranes. As a consequence it can be postulated that, in order to be significant, future studies on the early events leading to cataractous disturbances must be carried out using a combination of histochemical, immunohistochemical and regional biochemical approaches.

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          Author and article information

          Journal
          ORE
          Ophthalmic Res
          10.1159/issn.0030-3747
          Ophthalmic Research
          S. Karger AG
          978-3-8055-6245-4
          978-3-318-01917-9
          0030-3747
          1423-0259
          1995
          1995
          11 December 2009
          : 27
          : Suppl 1
          : 78-85
          Affiliations
          Department of Morphology The Netherlands Ophthalmic Research Institute, Amsterdam, The Netherlands
          Article
          267846 Ophthalmic Res 1995;27:78–85
          10.1159/000267846
          8577466
          © 1995 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 8
          Categories
          Contributions to Lens-Morphology, -Physiology, -Biochemistry and -Pharmacology

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