12
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Predictive biomarkers in PD-1/PD-L1 checkpoint blockade immunotherapy.

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Checkpoint blockades turn on a new paradigm shift in immunotherapy for cancer. Remarkable clinical efficacy, durable response and low toxicity of programmed death 1 (PD-1)/programmed death ligand-1 (PD-L1) checkpoint blockades have been observed in various malignancies. However, a lot of cancer patients failed to respond to the PD-1/PD-L1 checkpoint blockades. It is crucial to identify a biomarker to predict the response to checkpoint blockades. The overexpression of PD-L1 is an important and widely-explored predictive biomarker for the response to PD-1/PD-L1 antibodies. However PD-L1 staining cannot be used to accurately select patients for PD-1/PD-L1 pathway blockade due to the low prediction accuracy and dynamic changes. Tumor-infiltrating immune cells and molecules in the tumor microenvironment, or along with PD-L1 expression, may be important in predicting clinical benefits of PD-1/PD-L1 checkpoint blockades. Gene analysis has proven to be new approach for judging the potential clinical benefit of immune checkpoint inhibitors, such as mutational landscape and mismatch-repair deficiency. Further preclinical and clinical studies are necessary to carry out before its application in clinical practice. Challenges should be overcome to identify patients accurately who will benefit from PD-1/PD-L1 checkpoint blockades. In this review, we focus on the predictive biomarkers for checkpoint blockades of PD-1/PD-L1 pathway.

          Related collections

          Author and article information

          Journal
          Cancer Treat. Rev.
          Cancer treatment reviews
          1532-1967
          0305-7372
          Dec 2015
          : 41
          : 10
          Affiliations
          [1 ] Department of Radiation Oncology and Shandong Key Laboratory of Radiation Oncology, Shandong Cancer Hospital and Institute, Jinan, Shandong, China.
          [2 ] Department of Radiology, Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, China.
          [3 ] Department of Radiation Oncology and Shandong Key Laboratory of Radiation Oncology, Shandong Cancer Hospital and Institute, Jinan, Shandong, China. Electronic address: xinglg@medmail.com.cn.
          [4 ] Department of Radiation Oncology and Shandong Key Laboratory of Radiation Oncology, Shandong Cancer Hospital and Institute, Jinan, Shandong, China. Electronic address: sdyujinming@126.com.
          Article
          S0305-7372(15)00196-6
          10.1016/j.ctrv.2015.11.001
          26589760
          232d2b93-a08f-44ef-89e6-d4eda1decfea
          Copyright © 2015 Elsevier Ltd. All rights reserved.
          History

          Biomarkers,Immunotherapy,PD-1,PD-L1,Response
          Biomarkers, Immunotherapy, PD-1, PD-L1, Response

          Comments

          Comment on this article